Results 111 to 120 of about 870,116 (308)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide Hydrolase

, 2011
Mauro Mileni, Joie Garfunkle, Cyrine Ezzili, Benjamin F. Cravatt, Raymond C. Stevens, Dale L. Boger   +5 more
openalex   +2 more sources

Salivary Antigen-5/CAP Family Members Are Cu2+-dependent Antioxidant Enzymes That Scavenge O2⨪ and Inhibit Collagen-induced Platelet Aggregation and Neutrophil Oxidative Burst [PDF]

, 2013
Teresa C. F. Assumpção, Dongying Ma, Alexandra Schwarz, Karine Reiter, Jaime M. Santana, John F. Andersen, José M. C. Ribeiro, Glenn Nardone, Lee L. Yu, Ivo M.B. Francischetti   +9 more
openalex   +1 more source

Angiotensin‐Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia

, 2021
Young Hee Nam, Colleen Brensinger, Warren B. Bilker, James Flory, Charles E. Leonard, Sean Hennessy   +5 more
openalex   +2 more sources

Supplementary Figure 5 from The NEDD8-Activating Enzyme Inhibitor, MLN4924, Cooperates with TRAIL to Augment Apoptosis through Facilitating c-FLIP Degradation in Head and Neck Cancer Cells [PDF]

, 2023
Liqun Zhao, Ping Yue, Sagar Lonial, Fadlo R. Khuri, Shi‐Yong Sun   +4 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Design and green synthesis of 2-(diarylalkyl)aminobenzothiazole derivatives and their dual activities as angiotensin converting enzyme inhibitors and calcium channel blockers

, 2014
Praveen Kumar Kalavagunta, Pankaj K. Bagul, Anvesh Jallapally, Srinivas Kantevari, S. Banerjee, Ravirala Narender   +5 more
openalex   +1 more source

Analysis of the combined effect of two linear inhibitors on a single enzyme [PDF]

, 1998
Juan J. Martínez‐Irujo, María Luisa Villahermosa, Javier Mercapide, Jesús F. Cabodevilla, Esteban Santiago   +4 more
openalex   +1 more source

Should Angiotensin-Converting Enzyme Inhibitors ever Be Used for the Management of Hypertension? [PDF]

, 2020
Jeffrey M. Turner, Ravi Kodali
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source