Results 11 to 20 of about 870,116 (308)

Sulfa-drugs as Topic for Secondary School Chemistry – Effects, Side Effects and Structural Causes

CHIMIA, 2021
The topic 'Sulfa-Drugs in secondary school chemistry' has been developed in cooperation of three high schools (Kantonsschulen). Three essential aspects are covered that ideally complement each other: 1.
Roger Deuber, Urs Leisinger, Amadeus Bärtsch   +2 more
doaj   +1 more source

Cryptic Metabolites from Marine-Derived Microorganisms Using OSMAC and Epigenetic Approaches

Marine Drugs, 2022
Marine microorganisms have proven to be a source of new natural products with a wide spectrum of biological activities relevant in different industrial sectors.
Cristina Pinedo-Rivilla, Josefina Aleu, Rosa Durán-Patrón   +2 more
doaj   +1 more source

Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can
Mothana K. Al-Omari, Mai Elaarag, Raed M. Al-Zoubi, Ahmad R. Al-Qudimat, Ayman A. Zarour, Enas A. Al-Hurani, Zainab E. Fares, Leena M. Alkharraz, Mohanad Shkoor, Abdulilah D. Bani-Yaseen, Omar M. Aboumarzouk, Aksam Yassin, Abdulla A. Al-Ansari   +12 more
doaj   +1 more source

Medium-Intensity Treadmill Exercise Exerts Beneficial Effects on Bone Modeling Through Bone Marrow Mesenchymal Stromal Cells

Frontiers in Cell and Developmental Biology, 2020
As a type of multipotential cells, bone marrow mesenchymal stromal cells (BMMSCs) can differentiate into chondrocytes, osteoblasts, and adipocytes under different loading condition or specific microenvironment. Previous studies have shown that BMMSCs and
Lingli Zhang, Yu Yuan, Wei Wu, Zhongguang Sun, Le Lei, Jing Fan, Bo Gao, Jun Zou   +7 more
doaj   +1 more source

Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.

Biology, 2020
Matthiola incana (L.) R. Br. (Brassicaceae) is widely cultivated for ornamental purposes and utilized as a medicinal plant. In the present work, the hydroalcoholic extract from the aerial parts of this species has been evaluated in different bioassays in
Maria Fernanda Taviano, Natalizia Miceli, Rosaria Acquaviva, Giuseppe Antonio Malfa, Salvatore Ragusa, Deborah Giordano, Guillermo Cásedas, Francisco Les, Víctor López   +8 more
doaj   +1 more source

The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues

Molecules, 2019
We recently reported that SF2312 ((1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid), a phosphonate antibiotic with a previously unknown mode of action, is a potent inhibitor of the glycolytic enzyme, Enolase.
Federica Pisaneschi, Yu-Hsi Lin, Paul G. Leonard, Nikunj Satani, Victoria C. Yan, Naima Hammoudi, Sudhir Raghavan, Todd M. Link, Dimitra K. Georgiou, Barbara Czako, Florian L. Muller   +10 more
doaj   +1 more source

Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design, Synthesis, Biological Evaluation, and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity

Molecules, 2020
A series of Bis-pyrazole Schiff bases (6a–d and 7a–d) and mono-pyrazole Schiff bases (8a–d and 9a–d) were designed and synthesized through the reaction of 5-aminopyrazoles 1a–d with aldehydes 2–5 using mild reaction condition with a good yield percentage.
Ashraf S. Hassan, Ahmed A. Askar, Ahmed M. Naglah, Abdulrahman A. Almehizia, Ahmed Ragab   +4 more
doaj   +1 more source

Biological Evaluation and Molecular Docking with In Silico Physicochemical, Pharmacokinetic and Toxicity Prediction of Pyrazolo[1,5-a]pyrimidines

Molecules, 2020
Pyrazolo[1,5-a]pyrimidines 5a−c, 9a−c and 13a−i were synthesized for evaluation of their in vitro antimicrobial properties against some microorganisms and their immunomodulatory activity.
Ahmed M. Naglah, Ahmed A. Askar, Ashraf S. Hassan, Tamer K. Khatab, Mohamed A. Al-Omar, Mashooq A. Bhat   +5 more
doaj   +1 more source

A metal-based inhibitor of NEDD8-activating enzyme. [PDF]

PLoS ONE, 2012
A cyclometallated rhodium(III) complex [Rh(ppy)(2)(dppz)](+) (1) (where ppy=2-phenylpyridine and dppz=dipyrido[3,2-a:2',3'-c]phenazine dipyridophenazine) has been prepared and identified as an inhibitor of NEDD8-activating enzyme (NAE).
Hai-Jing Zhong, Hui Yang, Daniel Shiu-Hin Chan, Chung-Hang Leung, Hui-Min Wang, Dik-Lung Ma   +5 more
doaj   +1 more source

Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationships

Molecules, 2013
With the widespread use of O-alkoxyresorufin dealkylation assays since the 1990s, thousands of inhibitors of cytochrome P450 family 1 enzymes (P450s 1A1, 1A2, and 1B1) have been identified and studied.
Jiawang Liu, Jayalakshmi Sridhar, Maryam Foroozesh   +2 more
doaj   +1 more source