Results 11 to 20 of about 517,918 (147)
Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]
, 2008 Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Blewett, Ann +6 more
core +4 more sources
The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues
Molecules, 2019 We recently reported that SF2312 ((1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid), a phosphonate antibiotic with a previously unknown mode of action, is a potent inhibitor of the glycolytic enzyme, Enolase.
Federica Pisaneschi +10 more
doaj +1 more source
A Review on the Structure and Anti-Diabetic (Type 2) Functions of β-Glucans
Foods, 2021 Type 2 diabetes, a long-term chronic metabolic disease, causes severe and increasing economic and health problems globally. There is growing evidence that β-glucans can function as bioactive macromolecules that help control type 2 diabetes with minimal ...
Yujun Wan +3 more
doaj +1 more source
Reduced glutamine synthetase activity alters the fecundity of female Bactrocera dorsalis (Hendel) [PDF]
, 2019 Glutamine synthetase (GS) is a key enzyme in glutamine synthesis and is associated with multiple physiological processes in insects, such as embryonic development, heat shock response, and fecundity regulation.
Smagghe, Guy +5 more
core +2 more sources
Molecules, 2023 Planar chromatography has recently been combined with six different effect-directed assays for three golden root (Rhodiola rosea L.) samples. However, the profiles obtained showed an intense tailing, making zone differentiation impossible.
Hanna Nikolaichuk +2 more
doaj +1 more source
Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationships
Molecules, 2013 With the widespread use of O-alkoxyresorufin dealkylation assays since the 1990s, thousands of inhibitors of cytochrome P450 family 1 enzymes (P450s 1A1, 1A2, and 1B1) have been identified and studied.
Jiawang Liu +2 more
doaj +1 more source
Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation
Toxins, 2016 Snake venom metalloproteinases (SVMPs) are abundant in the venoms of vipers and rattlesnakes, playing important roles for the snake adaptation to different environments, and are related to most of the pathological effects of these venoms in human victims.
Ana M. Moura-da-Silva +5 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can
Mothana K. Al-Omari +12 more
doaj +1 more source
Kinetic and thermodynamic analysis of leech-derived tryptase inhibitor interaction with bovine tryptase and bovine trypsin [PDF]
, 2000 The interaction of leech-derived tryptase inhibitor (LDTI) with bovine liver capsule tryptase (BLCT) and bovine trypsin has been studied using both thermodynamic and kinetic approaches.
Auerswald E.A. +6 more
core +1 more source
A metal-based inhibitor of NEDD8-activating enzyme. [PDF]
PLoS ONE, 2012 A cyclometallated rhodium(III) complex [Rh(ppy)(2)(dppz)](+) (1) (where ppy=2-phenylpyridine and dppz=dipyrido[3,2-a:2',3'-c]phenazine dipyridophenazine) has been prepared and identified as an inhibitor of NEDD8-activating enzyme (NAE).
Hai-Jing Zhong +5 more
doaj +1 more source