Results 11 to 20 of about 1,349,855 (362)
Sulfa-drugs as Topic for Secondary School Chemistry – Effects, Side Effects and Structural Causes
CHIMIA, 2021 The topic 'Sulfa-Drugs in secondary school chemistry' has been developed in cooperation of three high schools (Kantonsschulen). Three essential aspects are covered that ideally complement each other: 1.
Roger Deuber +2 more
doaj +1 more source
Crystal structures of trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes [PDF]
, 2013 Oligopeptidase B cleaves after basic amino acids in peptides up to 30 residues. As a virulence factor in bacteria and trypanosomatid pathogens that is absent in higher eukaryotes, this is a promising drug target.
Canning, Peter +3 more
core +10 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can
Mothana K. Al-Omari +12 more
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Flavivirus enzymes and their inhibitors
, 2021 Flaviviruses such as dengue, Japanese encephalitis, West Nile, Yellow Fever and Zika virus, cause viral hemorrhagic fever and encephalitis in humans. However, antiviral therapeutics to treat or prevent flavivirus infections are not yet available. Thus, there is pressing need to develop therapeutics and vaccines that target flavivirus infections.
Marc C. Morais +2 more
openaire +4 more sources
Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]
, 2008 Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Blewett, Ann +6 more
core +4 more sources
Reduced glutamine synthetase activity alters the fecundity of female Bactrocera dorsalis (Hendel) [PDF]
, 2019 Glutamine synthetase (GS) is a key enzyme in glutamine synthesis and is associated with multiple physiological processes in insects, such as embryonic development, heat shock response, and fecundity regulation.
Smagghe, Guy +5 more
core +2 more sources
The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues
Molecules, 2019 We recently reported that SF2312 ((1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid), a phosphonate antibiotic with a previously unknown mode of action, is a potent inhibitor of the glycolytic enzyme, Enolase.
Federica Pisaneschi +10 more
doaj +1 more source
Molecules, 2020 Pyrazolo[1,5-a]pyrimidines 5a−c, 9a−c and 13a−i were synthesized for evaluation of their in vitro antimicrobial properties against some microorganisms and their immunomodulatory activity.
Ahmed M. Naglah +5 more
doaj +1 more source
A metal-based inhibitor of NEDD8-activating enzyme. [PDF]
PLoS ONE, 2012 A cyclometallated rhodium(III) complex [Rh(ppy)(2)(dppz)](+) (1) (where ppy=2-phenylpyridine and dppz=dipyrido[3,2-a:2',3'-c]phenazine dipyridophenazine) has been prepared and identified as an inhibitor of NEDD8-activating enzyme (NAE).
Hai-Jing Zhong +5 more
doaj +1 more source
Plants, 2022 Aristotelia chilensis is a plant whose fruit is considered a powerful natural antioxidant. During the last years, some investigations of the fruit have been carried out, finding antioxidant properties in the juice or the phenolic fraction.
Adriana Pineda +3 more
doaj +1 more source