Results 21 to 30 of about 517,918 (147)

Sulfa-drugs as Topic for Secondary School Chemistry – Effects, Side Effects and Structural Causes

CHIMIA, 2021
The topic 'Sulfa-Drugs in secondary school chemistry' has been developed in cooperation of three high schools (Kantonsschulen). Three essential aspects are covered that ideally complement each other: 1.
Roger Deuber, Urs Leisinger, Amadeus Bärtsch   +2 more
doaj   +1 more source

Inhibitory Effect of Bovine Lactoferrin on Catechol-O-Methyltransferase

Molecules, 2017
Lactoferrin (LF) is a well-known multifunctional protein. In this study, we report the inhibitory potency of bovine LF (bLF) on catechol-O-methyltransferase (COMT), which catalyzes methylation of catechol substrates.
Masayuki Ikeda, Hiroshi Iijima, Ichizo Shinoda, Hiroshi Iwamoto, Yasuhiro Takeda   +4 more
doaj   +1 more source

Guianensin, a Simulium guianense salivary protein, has broad anti-hemostatic and anti-inflammatory properties

Frontiers in Immunology, 2023
BackgroundSalivary glands from blood-feeding arthropods secrete several molecules that inhibit mammalian hemostasis and facilitate blood feeding and pathogen transmission.
Paola Carolina Valenzuela-Leon, Andrezza Campos Chagas, Ines Martin-Martin, Adeline E. Williams, Markus Berger, Gaurav Shrivastava, Andrew S. Paige, Michalis Kotsyfakis, Michalis Kotsyfakis, Lucas Tirloni, Eric Calvo   +10 more
doaj   +1 more source

Substrate-Specific Inhibition Constants for Phospholipase A2 Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics. [PDF]

, 2019
Assaying lipolytic enzymes is extremely challenging because they act on water-insoluble lipid substrates, which are normally components of micelles, vesicles, and cellular membranes.
Armando, Aaron, Dennis, Edward A, Mouchlis, Varnavas D   +2 more
core   +6 more sources

Marine Natural Products from Indonesian Waters

Marine Drugs, 2019
Natural products are primal and have been a driver in the evolution of organic chemistry and ultimately in science. The chemical structures obtained from marine organisms are diverse, reflecting biodiversity of genes, species and ecosystems. Biodiversity
Novriyandi Hanif, Anggia Murni, Chiaki Tanaka, Junichi Tanaka   +3 more
doaj   +1 more source

Screening of Tyrosinase, Xanthine Oxidase, and α-Glucosidase Inhibitors from Polygoni Cuspidati Rhizoma et Radix by Ultrafiltration and HPLC Analysis

Molecules, 2023
Polygoni Cuspidati Rhizoma et Radix (PCR), the rhizome and root of Polygonum cuspidatum Sieb. et Zucc., has been used as an herbal medicine for a long time. In this study, the ultrafiltration combined with high performance liquid chromatography (UF-HPLC)
Jing Chen, Qi Huang, Zhuobin He, Guoying Tan, Yuansheng Zou, Juying Xie, Zhengming Qian   +6 more
doaj   +1 more source

Biosynthesis and enzymology of the Caenorhabditis elegans cuticle: identification and characterization of a novel serine protease inhibitor. [PDF]

, 2006
The nematode Caenorhabditis elegans represents an excellent model in which to examine nematode gene expression and function. A completed genome, straightforward transgenesis, available mutants and practical genome-wide RNAi approaches provide an ...
Andrew J. Birnie, Antony P. Page, Brenner, Brooks, Canty, Chu, Davis, Edens, Eschenlauer, Frand, Friedman, Gillian McCormack, Hawdon, Hill, Johnstone, Kamath, Kamath, Kramerova, Kramerova, Kress, Lustigman, Milstone, Myllyharju, Myllyharju, Novelli, Page, Page, Page, Page, Page, Pappano, Peters, Poole, Roberts, Sapio, Simmer, Singh, Sulston, Thacker, Thacker, Thein, Winter, Yang   +42 more
core   +1 more source

Insights and Ideas Garnered from Marine Metabolites for Development of Dual-Function Acetylcholinesterase and Amyloid-β Aggregation Inhibitors

Marine Drugs, 2014
Due to the diversity of biological activities that can be found in aquatic ecosystems, marine metabolites have been an active area of drug discovery for the last 30 years.
Shana V. Stoddard, Mark T. Hamann, Randy M. Wadkins   +2 more
doaj   +1 more source

Cryptic Metabolites from Marine-Derived Microorganisms Using OSMAC and Epigenetic Approaches

Marine Drugs, 2022
Marine microorganisms have proven to be a source of new natural products with a wide spectrum of biological activities relevant in different industrial sectors.
Cristina Pinedo-Rivilla, Josefina Aleu, Rosa Durán-Patrón   +2 more
doaj   +1 more source

Synergistic Antifungal Effect of Fluconazole Combined with Licofelone against Resistant Candida albicans

Frontiers in Microbiology, 2017
Candida albicans (C. albicans) is one of the important opportunistic fungal pathogens that is closely associated with disseminated or chronic infections. The objective of this study is to evaluate the synergistic antifungal effect of licofelone, which is
Xinning Liu, Xinning Liu, Tao Li, Decai Wang, Yilei Yang, Wenwen Sun, Jianqiao Liu, Shujuan Sun   +7 more
doaj   +1 more source