Results 21 to 30 of about 1,349,855 (362)
Frontiers in Cell and Developmental Biology, 2020 As a type of multipotential cells, bone marrow mesenchymal stromal cells (BMMSCs) can differentiate into chondrocytes, osteoblasts, and adipocytes under different loading condition or specific microenvironment. Previous studies have shown that BMMSCs and
Lingli Zhang +7 more
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A Review on the Structure and Anti-Diabetic (Type 2) Functions of β-Glucans
Foods, 2021 Type 2 diabetes, a long-term chronic metabolic disease, causes severe and increasing economic and health problems globally. There is growing evidence that β-glucans can function as bioactive macromolecules that help control type 2 diabetes with minimal ...
Yujun Wan +3 more
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International Research Journal Of Pharmacy, 2021 Enzymes play very important role in living organism as biocatalyst. They play vital role like secretion, metabolism, digestion, DNA functions, reproduction, conversation of molecules and many other functions of body. By inhibiting specific enzymes, we can cure numerous pathological conditions in humans like inhibiting HMG CoA reductase, we can decrease
Vipul Vaghela +2 more
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Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationships
Molecules, 2013 With the widespread use of O-alkoxyresorufin dealkylation assays since the 1990s, thousands of inhibitors of cytochrome P450 family 1 enzymes (P450s 1A1, 1A2, and 1B1) have been identified and studied.
Jiawang Liu +2 more
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Perspective on the Structural Basis for Human Aldo-Keto Reductase 1B10 Inhibition
Metabolites, 2021 Human aldo-keto reductase 1B10 (AKR1B10) is overexpressed in many cancer types and is involved in chemoresistance. This makes AKR1B10 to be an interesting drug target and thus many enzyme inhibitors have been investigated.
Francesc Xavier Ruiz +2 more
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Angiotensin-Converting Enzyme Inhibitors [PDF]
The Journal of Clinical Hypertension, 2011 KEY POINTS AND RECOMMENDATIONS: • In addition to hypertension, angiotensin-converting enzyme inhibitors are indicated for treatment of patients at high risk for coronary artery disease, after myocardial infarction, with dilated cardiomypathy, or with chronic kidney disease.
Joseph L. Izzo, Matthew R. Weir
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Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation
Toxins, 2016 Snake venom metalloproteinases (SVMPs) are abundant in the venoms of vipers and rattlesnakes, playing important roles for the snake adaptation to different environments, and are related to most of the pathological effects of these venoms in human victims.
Ana M. Moura-da-Silva +5 more
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Biology, 2020 Matthiola incana (L.) R. Br. (Brassicaceae) is widely cultivated for ornamental purposes and utilized as a medicinal plant. In the present work, the hydroalcoholic extract from the aerial parts of this species has been evaluated in different bioassays in
Maria Fernanda Taviano +8 more
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Molecules, 2020 A series of Bis-pyrazole Schiff bases (6a–d and 7a–d) and mono-pyrazole Schiff bases (8a–d and 9a–d) were designed and synthesized through the reaction of 5-aminopyrazoles 1a–d with aldehydes 2–5 using mild reaction condition with a good yield percentage.
Ashraf S. Hassan +4 more
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Molecules, 2023 Planar chromatography has recently been combined with six different effect-directed assays for three golden root (Rhodiola rosea L.) samples. However, the profiles obtained showed an intense tailing, making zone differentiation impossible.
Hanna Nikolaichuk +2 more
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