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3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Structure, Biochemistry and Comparative Aspects of Mammalian Seminal Plasma Acrosin Inhibitors [PDF]

, 1976
Fink, Edwin, Fritz, Hans, Klauser, R., Kupfer, S., Peeters, H., Tschesche, Harald   +5 more
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Decreased vascular responsiveness produced by angiotensin-converting enzyme inhibitors in the rat isolated kidney.

, 1982
Satoru Chiba, C P Quilley, J C McGiff
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Pyranoid Spirosugars as Enzyme Inhibitors

Current Organic Synthesis, 2021
Background: Pyranoid spirofused sugar derivatives represent a class of compounds with a significant impact in the literature. From the structural point of view, the rigidity inferred by the spirofused entity has made these compounds object of interest mainly as enzymatic inhibitors, in particular, carbohydrate processing enzymes.
La Ferla, Barbara, D'Orazio, Giuseppe
openaire   +4 more sources

Inhibitors of glyoxalase enzymes

Biochemical and Biophysical Research Communications, 1980
Abstract Both glyoxalase enzymes from various sources are inhibited by nucleotides, nucleosides and a series of structurally related compounds in an apparently cooperative manner. In general, aromatic compounds, which contain heterocyclic nitrogen and/or have amino groups on the aromatic ring, are effective inhibitors of these enzymes.
B. Oray, B. Oray, Scott J. Norton, Scott J. Norton   +3 more
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Enzyme Inhibitors in the Treatment of Hypertension.

Annals of Internal Medicine, 1961
Excerpt The use of enzyme inhibitors in the treatment of hypertension is currently being investigated.
John H. Moyer, Albert N. Brest
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Angiotensin-Converting Enzyme Inhibitors

Journal of Hypertension, 1991
The introduction of angiotensin-converting enzyme (ACE) inhibitors for the treatment of hypertension and heart failure is probably the most important advance in cardiovascular pharmacotherapy in the last few decades. Although the role of the renin-angiotensin system (RAS) in cardiovascular diseases had been investigated extensively for more than 70 yr,
Irene Gavras, Haralambos Gavras
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Enzyme kinetics in relation to enzyme inhibitors

Biochemical Pharmacology, 1973
Abstract A Large number of pharmacologically important compounds have been found to act as enzyme inhibitors and a kinetic study of the inhibitory process can provide important information on the potency of the compound and on its mode of interaction with the enzyme.
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Inhibitors of Kinin-Forming Enzymes

Agents and Actions, 1976
The typical trypsin-like protease in animals were plasmin, kallikrein, thrombin, factor X, XI, XII, cathepsin B, plasminogen tissue activator and urokinase, and so on. Among them plasmin and kallikrein have kinin-forming activity. A synthetic reversible inhibitor of plasmin, and anticoagulant factor of blood, has been extensively studied.
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