Results 51 to 60 of about 517,918 (147)

Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs

Drug Design, Development and Therapy, 2020
Jens Hagenow,1 Stefanie Hagenow,1 Kathrin Grau,1 Mohammad Khanfar,1– 3 Lena Hefke,4 Ewgenij Proschak,4 Holger Stark1 1Heinrich Heine University Düsseldorf, Institute of Pharmaceutical and Medicinal Chemistry, Duesseldorf 40225, Germany ...
Hagenow J, Hagenow S, Grau K, Khanfar M, Hefke L, Proschak E, Stark H   +6 more
doaj  

Identification of a peptide ligand for human ALDH3A1 through peptide phage display: Prediction and characterization of protein interaction sites and inhibition of ALDH3A1 enzymatic activity

Frontiers in Molecular Biosciences, 2023
Aldehyde dehydrogenase 3A1 (ALDH3A1) by oxidizing medium chain aldehydes to their corresponding carboxylic acids, is involved in the detoxification of toxic byproducts and is considered to play an important role in antioxidant cellular defense.
Georgia-Persephoni Voulgaridou, Vasileios Theologidis, Vasileios Xanthis, Eleni Papagiannaki, Ilias Tsochantaridis, Vasiliki E. Fadouloglou, Aglaia Pappa   +6 more
doaj   +1 more source

The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. [PDF]

, 2010
Deregulation of the phosphoinositide-3-OH kinase (PI(3)K) pathway has been implicated in numerous pathologies including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma.
Alex Berndt, Benjamin T Houseman, Christian Rommel, Daniel D Le, Fabrice Gorrec, Jeffrey P Shaw, Joseph I Pacold, Kevan M Shokat, Matthias K Schwarz, Olusegun Williams, Pascale Gaillard, Pingda Ren, Roger L Williams, Simon Miller, Thomas Rückle, Wai-Ching Hon, Yi Liu   +16 more
core   +2 more sources

Theory on the rate equations of Michaelis-Menten type enzyme kinetics with competitive inhibition.

PLoS ONE
We derive approximate expressions for pre- and post-steady state regimes of the velocity-substrate-inhibitor spaces of the Michaelis-Menten enzyme kinetic scheme with fully and partial competitive inhibition.
Rajamanickam Murugan
doaj   +1 more source

Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX

Molecules, 2018
A series of carboxamide derivatives of 6- and 7-substituted coumarins have been prepared by an original procedure starting from the corresponding 6- or 7-hydroxycoumarins which were alkylated with ethyl iodoacetate, and the obtained ester was converted ...
Aikaterini Peperidou, Silvia Bua, Murat Bozdag, Dimitra Hadjipavlou-Litina, Claudiu T. Supuran   +4 more
doaj   +1 more source

Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]

, 2012
Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone, Rajalingam, Krishnaraj, Dikic, Ivan   +2 more
core   +1 more source

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]

, 2006
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi S., Appel, Kurt, Bhatia, Harsharan S., Candelario-Jalil, Eduardo, Fiebich, Bernd L., Hull, Michael, Lieb, Klaus, Munoz, Eduardo   +7 more
core   +1 more source

Barnyardgrass (Echinochloa crus-galli (L.) P. Beauv.) resistance to acetolactate synthase-inhibiting and other herbicides in rice in Turkey

Plant, Soil and Environment, 2020
Barnyardgrass (Echinochloa crus-galli (L.) P. Beauv.) is one of the most yield-limiting weeds in rice in Turkey. Barnyardgrass resistance to common herbicides has been reported worldwide; however, such information is largely lacking in the country.
Koray Kacan, Nihat Tursun, Hayat Ullah, Avishek Datta   +3 more
doaj   +1 more source

ATP mediates both activation and inhibition of K(ATP) channel activity via cAMP-dependent protein kinase in insulin-secreting cell lines. [PDF]

, 1989
The single-channel recording technique was employed to investigate the mechanism conferring ATP sensitivity to a metabolite-sensitive K channel in insulin-secreting cells.
Ciani, S, Eddlestone, GT, Ribalet, B
core  

Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G [PDF]

, 2005
BACKGROUND: In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated whether saturated FFA induce apoptosis
Mishra, Rangnath, Simonson, Michael S
core   +3 more sources