Results 201 to 210 of about 700,443 (307)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Discovery and development of steroidal enzyme inhibitors as anti-cancer drugs: state-of-the-art and future perspectives. [PDF]

J Enzyme Inhib Med Chem
Cerra B, Gioiello A.
europepmc   +1 more source

Telfairia occidentalis Ameliorates Streptozotocin-induced Testicular Oxidative stress by Restoring Endogenous Antioxidant Enzyme Activity and Inhibiting Apoptosis, and Pro-inflammatory cytokines

Ujong Peter Ujong, Edward Emuru Odey
openalex   +2 more sources

Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema

, 2013
Guillaume Paré, Michiaki Kubo, James Brian Byrd, Catherine A. McCarty, Alencia Woodard‐Grice, Koon Teo, Sonia S. Anand, Rebecca L. Zuvich, Yuki Bradford, Stephanie Ross, Yusuke Nakamura, Marylyn D. Ritchie, Nancy J. Brown   +12 more
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Withholding vs. continuing angiotensin-converting enzyme inhibitors or angiotensin receptor blockers before surgery: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Ann Med
Dou W, Hu JH, Long YQ, Liu H, Ji FH, Sudhan N, Peng K.   +6 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Demystifying Functional Parameters for Irreversible Enzyme Inhibitors. [PDF]

J Med Chem
Heppner DE, Ogboo BC, Urul DA, May EW, Schaefer EM, Murkin AS, Gehringer M.   +6 more
europepmc   +1 more source

Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes

, 2005
Shaukath Ara Khanum, Satish Kumar Murari, Bannikuppe Sannanaik Vishwanth, S. Shashikanth   +3 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source