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Angiotensin-converting enzyme inhibitors
2001Publisher Summary Angiotensin-converting enzyme (ACE) inhibitors were first studied clinically in the 1970s. ACE inhibitors were discovered by taking advantage of previous basic research on the physiology of sodium, potassium, and water homeostasis and blood pressure regulation, in a reciprocal way ACE have also advanced research in this field, and ...
J, Menard, A A, Patchett
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Angiotensin-Converting Enzyme Inhibitors
Medical Clinics of North America, 1988There is convincing evidence that ACE inhibitors, alone or in combination with a diuretic, effectively lower blood pressure in patients with all grades of essential or renovascular hypertension and that they are of particular benefit as adjunctive therapy in patients with congestive heart failure.
H H, Rotmensch +2 more
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Substrate-Selective Enzyme Inhibitors
Trends in Pharmacological Sciences, 2019Enzymes with multiple substrates pose a unique challenge for drug development because of an increased potential for on-target side effects. Maianti and colleagues (Nat. Chem. Biol., 2019) identify novel exo-site inhibitors with abilities to alter the substrate-selectivity of insulin-degrading enzymes (IDE).
Qian, Chu +2 more
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Angiotensin converting enzyme inhibitors
Pharmaceutisch Weekblad Scientific Edition, 1982Inhibition of angiotensin converting enzyme (ACE) in patients suffering from renovascular hypertension results in lowering of the blood-pressure. The development of captopril, an orally active ACE inhibitor and the structure-activity relationship of captopril analogues are described.
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Angiotensin-Converting Enzyme Inhibitors
Medical Clinics of North America, 1987In summary, ACE inhibitors are effective in reducing blood pressure as initial therapy in some hypertensive patients and in combination with diuretics and other agents in virtually all hypertensives. ACE inhibitors are uniquely advantageous because of their favorable hemodynamic effects, the lack of adverse metabolic effects, and their ability to ...
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Angiotensin-Converting Enzyme Inhibitors
AACN Advanced Critical Care, 1992The angiotensin-converting enzyme (ACE) inhibitors available today include Captopril (Capoten), enalapril (Vasotec), enaloprilat (Vasotec IV), lisinopril (Prinivil, Zestril), benazepril (Lotensin), fosinopril (Monopril), and ramipril (Atace). These drugs are used in the treatment of hypertension and congestive heart failure.
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Inhibitors of Kinin-Forming Enzymes
Agents and Actions, 1976The typical trypsin-like protease in animals were plasmin, kallikrein, thrombin, factor X, XI, XII, cathepsin B, plasminogen tissue activator and urokinase, and so on. Among them plasmin and kallikrein have kinin-forming activity. A synthetic reversible inhibitor of plasmin, and anticoagulant factor of blood, has been extensively studied.
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