Results 261 to 270 of about 5,417,177 (410)

Bioconversion and biosynthesis of 16-membered macrolide antibiotics. X. Final steps in the biosynthesis of spiramycin, using enzyme inhibitor: cerulenin.

, 1979
Satoshi Ōmura, CHIAKI KITAO, HIDETAKA HAMADA, Haruo Ikeda   +3 more
openalex   +2 more sources

Kinetics of irreversible enzyme inhibition by an unstable inhibitor [PDF]

, 1974
Emmanuel T. Rakitzis
openalex   +1 more source

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

FEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on cardiovascular outcomes in older adults with type 2 diabetes mellitus: a target trial emulation study. [PDF]

Cardiovasc Diabetol
Zeng W, Wang T, Stürmer T, He N, Shen P, Lin H, Guan X, Xu Y.   +7 more
europepmc   +1 more source

Bioconversion and biosynthesis of 16-membered macrolide antibiotic, tylosin, using enzyme inhibitor: Cerulenin.

, 1978
Satoshi Ōmura, CHIAKI KITAO, J. Miyazawa, Harumitsu Imai, Hideo Takeshima   +4 more
openalex   +2 more sources

Chemistry of enzyme inhibitors of microbial origin [PDF]

, 1973
H Umezawa
openalex   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Novel coumarin-based acetohydrazide-1,2,3-triazole derivatives as urease enzyme inhibitors: Synthesis, in vitro evaluation, and molecular dynamics simulation studies. [PDF]

Heliyon
Sepehrmansourie H, Azimi M, Ebadi A, Chehardoli G, Zolfigol MA, Amanlou M, Montazer MN, Mahdavi M, Najafi Z.   +8 more
europepmc   +1 more source

THE EFFECT OF ANGIOTENSIN I CONVERTING ENZYME INHIBITOR (SQ 20881) ON THE RELEASE OF PROSTAGLANDINS BY RABBIT KIDNEY, in vivo [PDF]

, 1977
Edward J. Johns, Robert Murdock, Bertha Singer   +2 more
openalex   +1 more source

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source