Results 41 to 50 of about 5,024,684 (342)

Association Between Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Suicide

JAMA Network Open, 2019
Key Points Question Are angiotensin receptor blockers associated with a higher risk of suicide than angiotensin-converting enzyme inhibitors? Findings In this case-control study of 964 older adults who died by suicide and 3856 matched control ...
M. Mamdani, T. Gomes, S. Greaves, Selina Manji, D. Juurlink, Mina Tadrous, S. Kennedy, T. Antoniou   +7 more
semanticscholar   +1 more source

Carbazole scaffolds in cancer therapy: a review from 2012 to 2018

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
For over half a century, the carbazole skeleton has been the key structural motif of many biologically active compounds including natural and synthetic products.
Samar Issa, Anthony Prandina, Nicolas Bedel, Pål Rongved, Saïd Yous, Marc Le Borgne, Zouhair Bouaziz   +6 more
doaj   +1 more source

Effectiveness of enzyme inhibitors in biomedicine and pharmacotherapy

Advances in Tissue Engineering & Regenerative Medicine Open Access, 2019
Enzymes are incredibly efficient biological catalysts that catalyze all cellular processes.1 However, several studies shed light on the importance of enzyme inhibitors in the pharmaceutical industry.2 The study of enzyme inhibitors has provided valuable ...
A. Ouertani, Mohamed Neifar, Rania Ouertani, A. Masmoudi, A. Cherif   +4 more
semanticscholar   +1 more source

Natural Products from Medicinal Plants with Anti-Human Coronavirus Activities

Molecules, 2021
Since the emergence of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) first reported in Wuhan, China in December 2019, COVID-19 has spread to all the continents at an unprecedented pace.
Salar Hafez Ghoran, Mohamed El-Shazly, Nazim Sekeroglu, Anake Kijjoa   +3 more
doaj   +1 more source

Influence of ultrasound and proteolytic enzyme inhibitors on muscle degradation, tenderness, and cooking loss of hens during aging

, 2018
Xiong G.-Y., Zhang L.-L., Zhang W., Wu J. (2012): Influence of ultrasound and proteolytic enzyme inhibitors on muscle degradation, tenderness, and cooking loss of hens during aging. Czech J. Food Sci., 30: 195–205.
G. Xiong, Li-li Zhang, Wei Zhang, Juan Wu   +3 more
semanticscholar   +1 more source

The GDP-Mannose Dehydrogenase of Pseudomonas aeruginosa: An Old and New Target to Fight against Antibiotics Resistance of Mucoid Strains

Antibiotics, 2023
Alginates play an important role in the resistance of mucoid strains of Pseudomonas aeruginosa to antibiotics, as well as their persistence by escaping the immune defense system.
Christian Hulen
doaj   +1 more source

S-Ethyl-Isothiocitrullin-Based Dipeptides and 1,2,4-Oxadiazole Pseudo-Dipeptides: Solid Phase Synthesis and Evaluation as NO Synthase Inhibitors

Molecules, 2023
We previously reported dipeptidomimetic compounds as inhibitors of neuronal and/or inducible NO synthases (n/iNOS) with significant selectivity against endothelial NOS (eNOS).
Elodie Mauchauffée, Jérémy Leroy, Jihanne Chamcham, Abdelaziz Ejjoummany, Manon Maurel, Lionel Nauton, Booma Ramassamy, Karima Mezghenna, Jean-Luc Boucher, Anne-Dominique Lajoix, Jean-François Hernandez   +10 more
doaj   +1 more source

In situ click chemistry generation of cyclooxygenase-2 inhibitors

Nature Communications, 2017
Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with several cancers and neurodegenerative diseases.
A. Bhardwaj, J. Kaur, M. Wuest, F. Wuest
semanticscholar   +1 more source

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

Science, 2020
Targeting a key enzyme in SARS-CoV-2 Scientists across the world are working to understand severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). Zhang et al.
Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, U. Curth, C. Drosten, Lucie Sauerhering, S. Becker, K. Rox, R. Hilgenfeld   +8 more
semanticscholar   +1 more source

Preparation of Alcohol Dehydrogenase–Zinc Phosphate Hybrid Nanoflowers through Biomimetic Mineralization and Its Application in the Inhibitor Screening

Molecules, 2023
A biomimetic mineralization method was used in the facile and rapid preparation of nanoflowers for immobilizing alcohol dehydrogenase (ADH). The method mainly uses ADH as an organic component and zinc phosphate as an inorganic component to prepare flower-
Mao-Ling Luo, Hua Chen, Guo-Ying Chen, Shengpeng Wang, Yitao Wang, Feng-Qing Yang   +5 more
doaj   +1 more source