Results 51 to 60 of about 8,754,571 (337)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Inhibitory effects against α-glucosidase and α-amylase of the flavonoids-rich extract from Scutellaria baicalensis shoots and interpretation of structure–activity relationship of its eight flavonoids by a refined assign-score method

Chemistry Central Journal, 2018
A flavonoids-rich extract of Scutellaria baicalensis shoots and its eight high content flavonoids were investigated for their inhibitory effects against α-glucosidase and α-amylase. Results show that abilities of the extract in inhibiting the two enzymes
Ke Li, Fan Yao, Qiang Xue, Hang Fan, Lingguang Yang, Xiang Li, Liwei Sun, Yujun Liu   +7 more
doaj   +1 more source

Chemical Composition, Antioxidant and Enzyme Inhibitory Activity of Onopordum caricum

Records of Natural Products, 2022
Plants are rich sources of biologically and/or pharmacologically active phytochemicals. This study aimed to determine the chemical composition, antioxidant, tyrosinase, anti-cholinesterase, and anti-diabetic activities of ethyl acetate (EtOAc), methanol (MeOH), and water extracts obtained from the aerial parts of Onopordum caricum (Hub.-Mor.), which is
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

In silico assessment of the inhibitory effect of four flavonoids (Chrysin, naringin, quercetin, kaempferol) on tyrosinase activity using the md simulation approach [PDF]

, 2020
Tyrosinase is a tetrameric enzyme that plays an important role in pigment production. Overproduction of melanin, which may lead to several skin disorders, is a result of tyrosinase activity.
GHORBANI, MOHAMAD, Shariatifar, H., NEMATOLLAH GHEIB, Gheibi, N., SHARIATIFAR, HANIFEH, Farasat, Alireza, Gheibi, Nematollah, MOHAMAD GHORBANI, ALIREZA FARASAT, Ghorbani, M., HANIFEH SHARIATIFAR, Farasat, A.   +11 more
core   +2 more sources

Enzyme Inhibitory Activities of Acetylene and Sesquiterpene Compounds in Atractylodes Rhizome.

Biological and Pharmaceutical Bulletin, 1993
In an attempt to elucidate the physiological activities of (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol diacetate (TDEYA), which was detected as a hydrolysis form (TDEY) in the plasma after oral administration of a decoction of Atractylodes rhizome in rats, we examined the inhibitory effects of various enzymes which are considered to participate in the ...
SAKURAI, Tetsuro, YAMADA, Hiroyuki, SAITO, Ken-ichi, KANO, Yoshihiro   +3 more
openaire   +3 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Recent Advances in the Biological Activity of s-Triazine Core Compounds

Pharmaceuticals, 2022
An effective strategy for successful chemotherapy relies on creating compounds with high selectivity against cancer cells compared to normal cells and relatively low cytotoxicity. One such approach is the discovery of critical points in cancer cells, i.e.
Dawid Maliszewski, Danuta Drozdowska
doaj   +1 more source

Inhibitory activities of baicalin against renin and angiotensin-converting enzyme

Pharmaceutical Biology, 2011
Baicalin has been characterized as the active compound and quality control marker in Scutellaria baicalensis Georgi, traditionally used as a hypotensive herb.To investigate the inhibitory activities of baicalin against renin and angiotensin-I converting enzyme (ACE) and their molecule mechanism of interactions.The fluorescence method using renin ...
Y F, Deng, R E, Aluko, Q, Jin, Y, Zhang, L J, Yuan   +4 more
openaire   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source