Results 41 to 50 of about 2,217,916 (339)
HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
Nature Communications, 2017 Clear cell renal cancers (ccRCC) display elevated intracellular lipid storage. Here the authors show that such lipid accumulation is due to the repression of carnitine palmitoyltransferase 1A (CPT1A) enzyme that impairs fatty acid (FA) transport into the
Weinan Du +11 more
doaj +1 more source
Phoresis and Enhanced Diffusion Compete in Enzyme Chemotaxis [PDF]
Nano Lett. 2018, 18, 4, 2711-2717, 2021 Chemotaxis of enzymes in response to gradients in the concentration of their substrate has been widely reported in recent experiments, but a basic understanding of the process is still lacking. Here, we develop a microscopic theory for chemotaxis, valid for enzymes and other small molecules.
arxiv +1 more source
PLoS Genetics, 2018 Scd6 protein family members are evolutionarily conserved components of translationally silent mRNA granules. Yeast Scd6 interacts with Dcp2 and Dhh1, respectively a subunit and a regulator of the mRNA decapping enzyme, and also associates with ...
Quira Zeidan +5 more
doaj +1 more source
Epigenetics & Chromatin, 2009 Background Pluripotency, the capacity for indefinite self-renewal and differentiation into diverse cell types is a unique state exhibited by embryonic stem (ES) cells.
Yeap Leng-Siew +2 more
doaj +1 more source
Nature Communications, 2019 Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in subsets of myeloid lineage cell types. Therefore, inhibition of the enzyme
L. Lama +23 more
semanticscholar +1 more source
XYLOSE ISOMERASE SYNTHESIS IN ACTINOBACTERIA ARTHROBACTER UREAFACIENS BIM B-6
Mìkrobìologìâ ì Bìotehnologìâ, 2008 The role of different carbon sources in biosynthesis of cell-bound xylose isomerase by Arthrobacter ureafaciens BIM B-6 was investigated. It was found that in this prokaryotic actinobacterium enzyme production is under control of induction and catabolite
Л. І. Сапунова
doaj +1 more source
The Methyltransferase Setd8 Is Essential for Erythroblast Survival and Maturation
Cell Reports, 2017 Erythropoiesis is a highly regulated process that generates enucleate red blood cells from committed erythroid progenitors. Chromatin condensation culminating in enucleation is a defining feature of this process.
Jeffrey Malik +4 more
doaj +1 more source
Accelerated search kinetics mediated by redox reactions of DNA repair enzymes [PDF]
Biophysical Journal, volume 96, pp 3949-3958, (2009), 2009 A Charge Transport (CT) mechanism has been proposed in several papers (e.g., Yavin, et al. PNAS, v102 3546 (2005)) to explain the localization of Base Excision Repair (BER) enzymes to lesions on DNA. The CT mechanism relies on redox reactions of iron-sulfur cofactors that modify the enzyme's binding affinity.
arxiv +1 more source
Bio-Protocol, 2020 Investigation of bacterial gene regulation upon environmental changes is still a challenging task. For example, Vibrio cholerae, a pathogen of the human gastrointestinal tract, faces diverse transient conditions in different compartments upon oral ...
Franz Zingl +3 more
doaj +1 more source
Modeling biological networks: from single gene systems to large microbial communities [PDF]
arXiv, 2021 In this research, we study biological networks at different scales: a gene autoregulatory network at the single-cell level and the gut microbiota at the population level. Proteins are the main actors in cells, they are the building blocks, act as enzymes and antibodies. The production of proteins is mediated by transcription factors. In some cases, a
arxiv