Results 81 to 90 of about 108,982 (307)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Isolation and characterization of an Arthrobacter strain 42-1 and study on the conditions for its sarcosine oxidase production

浙江大学学报. 农业与生命科学版, 2005
A sarcosine oxidase (SOX)-producing Athrobacter 42-1 was isolated from a chemostat enrichment of 42 ℃. The results showed that SOX from strain 42-1 was an induced enzyme and could be induced by reagents, such as sarcosine, creatine, creatinine and ...
ZHAO Geng-feng, MA Xiao-hang, JIA Xiao-ming, WANG Yuan-yuan   +3 more
doaj   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Nitrogen Repression of the Allantoin Degradative Enzymes in Saccharomyces cerevisiae [PDF]

Journal of Bacteriology, 1974
Saccharomyces cerevisiae can utilize allantoin as a sole nitrogen source by degrading it to ammonia, “CO 2 ,” and glyoxylate. We have previously shown that synthesis of the allantoin degradative enzymes is contingent upon the presence of allophanate, the last intermediate in the pathway.
J, Bossinger, R P, Lawther, T G, Cooper
openaire   +2 more sources

Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]

, 2014
microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei, Kim, Yun Ju, Maizel, Alexis   +2 more
core   +3 more sources

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Combination of ERG9 Repression and Enzyme Fusion Technology for Improved Production of Amorphadiene in Saccharomyces cerevisiae

Journal of Analytical Methods in Chemistry, 2013
The yeast strain (Saccharomyces cerevisiae) MTCC 3157 was selected for combinatorial biosynthesis of plant sesquiterpene amorpha-4,11-diene.
Rama Raju Baadhe, Naveen Kumar Mekala, Sreenivasa Rao Parcha, Yalavarthy Prameela Devi   +3 more
doaj   +1 more source

Role of Saccharomyces cerevisiae Nutrient Signaling Pathways During Winemaking: A Phenomics Approach

Frontiers in Bioengineering and Biotechnology, 2020
The ability of the yeast Saccharomyces cerevisiae to adapt to the changing environment of industrial processes lies in the activation and coordination of many molecular pathways. The most relevant ones are nutrient signaling pathways because they control
Beatriz Vallejo, Emilien Peltier, Emilien Peltier, Emilien Peltier, Victor Garrigós, Emilia Matallana, Philippe Marullo, Philippe Marullo, Agustín Aranda   +8 more
doaj   +1 more source

The 5' → 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development [PDF]

, 2012
XRN1 is a 5' → 3' processive exoribonuclease that degrades mRNAs after they have been decapped. It is highly conserved in all eukaryotes, including homologs in Drosophila melanogaster (Pacman), Caenorhabditis elegans (XRN1), and Saccharomyces cerevisiae (
Jones, Christopher Iain, Newbury, Sarah Faith, Zabolotskaya, Maria Vasilyevna   +2 more
core   +1 more source