Results 131 to 140 of about 560,659 (266)

Hereditary tyrosinemia type I-associated mutations in fumarylacetoacetate hydrolase reduce the enzyme stability and increase its aggregation rate. [PDF]

J Biol Chem, 2019
Macias I, Laín A, Bernardo-Seisdedos G, Gil D, Gonzalez E, Falcon-Perez JM, Millet O.   +6 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Immobilization of Thiol-Modified Horseradish Peroxidase on Gold Nanoparticles Enhances Enzyme Stability and Prevents Proteolytic Digestion. [PDF]

Langmuir
Breausche FE, Somerlot A, Walder J, Osei K, Okyem S, Driskell JD.   +5 more
europepmc   +1 more source

Increasing Enzyme Stability and Activity through Hydrogen Bond-Enhanced Halogen Bonds. [PDF]

Biochemistry, 2018
Carlsson AC, Scholfield MR, Rowe RK, Ford MC, Alexander AT, Mehl RA, Ho PS.   +6 more
europepmc   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Solvent concentration at 50% protein unfolding may reform enzyme stability ranking and process window identification. [PDF]

Nat Commun
Sorgenfrei FA, Sloan JJ, Weissensteiner F, Zechner M, Mehner NA, Ellinghaus TL, Schachtschabel D, Seemayer S, Kroutil W.   +8 more
europepmc   +1 more source

Glucose-6-phosphate dehydrogenase enzyme stability in filter paper dried blood spots. [PDF]

Clin Biochem, 2017
Flores SR, Hall EM, De Jesús VR.
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Horseradish Peroxidase Immobilized onto Mesoporous Magnetic Hybrid Nanoflowers for Enzymatic Decolorization of Textile Dyes: A Highly Robust Bioreactor and Boosted Enzyme Stability. [PDF]

ACS Omega
Bakar B, Akbulut M, Ulusal F, Ulu A, Özdemir N, Ateş B.   +5 more
europepmc   +1 more source

The combined effects of reactant kinetics and enzyme stability explain the temperature dependence of metabolic rates. [PDF]

Ecol Evol, 2017
DeLong JP, Gibert JP, Luhring TM, Bachman G, Reed B, Neyer A, Montooth KL.   +6 more
europepmc   +1 more source