Kinetic profiling of metabolic specialists demonstrates stability and consistency of in vivo enzyme turnover numbers [PDF]
, 2019 David Heckmann +8 more
openalex +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Non-Aqueous Biocatalysis in Homogeneous Solvent Systems
Food Technology and Biotechnology, 2004 Enzymes are highly specific catalysts that typically function in aqueous solvents. However, many enzymes retain their catalytic activities at high concentrations in non- aqueous environments, including neat hydrophilic organic solvents.
Sebastián Torres, Guillermo R. Castro
doaj
STABILITY OF Staphylococcus aureus BIOFILM AGAINST DIFFERENT CHEMICAL AGENTS AND SOME ENZYMES [PDF]
, 2016 Omar, Belal A.M. +3 more
openalex +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Thermoresponsive Poly(N,N-diethylacrylamide-co-glycidyl methacrylate) Copolymers and Its Catalytically Active α-Chymotrypsin Bioconjugate with Enhanced Enzyme Stability. [PDF]
Polymers (Basel), 2021 Kasza G +6 more
europepmc +1 more source
Effect of a double‐structured microporous polymer support on the catalytic activity, stability and aggregation behavior of immobilized enzymes [PDF]
, 2015 Hai‐Jie Yang +4 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Enzyme activity and stability of lactase immobilized on two different supports: Calcium alginate and magnetic chitosan [PDF]
, 2020 Farah Syafiqah Mohd Zawawi +3 more
openalex +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source