Results 91 to 100 of about 989,780 (312)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Design of stable metabolic networks [PDF]

, 2017
In this work, we propose eigenvalue optimization combined with Lyapunov theory concepts to ensure stability of the Embden—Meyerhof–Parnas pathway, the pentosephosphate pathway, the phosphotransferase system and fermentation reactions of Escherichia coli.
Bandoni, Jose Alberto, Blanco, Anibal Manuel, Di Maggio, Jimena Andrea, Diaz Ricci, Juan Carlos, Díaz, María Soledad   +4 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Support Materials of Organic and Inorganic Origin as Platforms for Horseradish Peroxidase Immobilization: Comparison Study for High Stability and Activity Recovery

Molecules
In the presented study, a variety of hybrid and single nanomaterials of various origins were tested as novel platforms for horseradish peroxidase immobilization.
Muhammad Bilal, Oliwia Degorska, Daria Szada, Agnieszka Rybarczyk, Agata Zdarta, Michal Kaplon, Jakub Zdarta, Teofil Jesionowski   +7 more
doaj   +1 more source

SIMPLE ENTRAPMENT OF ALCALASE IN DIFFERENT SILICA XEROGELS USING THE TWO STEPS SOL-GEL METHOD [PDF]

, 2011
The present study has focused on the entrapment of Alcalase in different xerogels obtained by using various molar ratios of methyltriethoxysilane, dimethyldietoxisilane and tetraethoxysilane.
Chiriac, A., Dudás, Zoltán Imre, Preda, Gabriela   +2 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Enhancing the Catalytic Performance of β-Mannanase via Polyvinyl Alcohol Immobilization and Genipin Modification

Molecules
This study reports the immobilization of β-mannanase from Aspergillus niger—either unmodified or genipin-modified—within polyvinyl alcohol hydrogels (PVA@mannanase and PVA@mannanase-Gen) for the enhanced production of mannooligosaccharides (MOSs).
Nazli Ece Varan Faki, Ali Toprak, Guzide Yucebilgic, Dilek Alagöz, Deniz Yildirim, Roberto Fernandez-Lafuente   +5 more
doaj   +1 more source

Enzymes by post—restriction enzyme stability [PDF]

Nature Biotechnology, 2000
J B, March, J, Clark
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Multi-in situ Electrochemical Impedance Analysis of Biofuel Cell Performance

Electrochemistry
Electrochemical impedance spectroscopy (EIS) provides valuable insights into the interfacial kinetics and mass-transport behavior of an electrochemical system.
Isao SHITANDA, Hiromichi INOUE, Noya LOEW, Yoshinao HOSHI, Hikari WATANABE, Masayuki ITAGAKI   +5 more
doaj   +1 more source