Results 101 to 110 of about 559,990 (314)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

ВЛИЯНИЕ РЕЖИМОВ ПРЕДВАРИТЕЛЬНОГО ЗАМОРАЖИВАНИЯ НА ЭФФЕКТИВНОСТЬ ЛИОФИЛИЗАЦИИ И АКТИВНОСТЬ ПРЕПАРАТА НА ОСНОВЕ КОЛЛАГЕНАЗ

Journal of Bioinformatics and Genomics
В работе исследовано влияние различных методов предварительного замораживания на эффективность последующей лиофилизации коллагеназы типа I и сохранение ее ферментативной активности.
Полякова А.О., Терлецкий В.П.   +1 more
doaj   +1 more source

Evaluation of pancreatin stability through enzyme activity determination

Acta Pharmaceutica, 2016
Pancreatin is a biotechnological product containing an enzyme complex, obtained from porcine pancreas, that is employed in treating pancreatic diseases.
Terra Gleysson De Paula, Vinícius De Farias Marcus, Trevisan Marcello Garcia, Garcia Jerusa Simone   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Purification, enzymatic properties, and stabilizer screening of acid protease from Trichoderma reesei

Shipin yu jixie
ObjectiveTo purify and study the enzymatic properties of acid protease from the Trichoderma reesei strain, and to screen the stabilizer formula.MethodsThe acid protease is purified by ammonium sulfate precipitation, dialysis, and anion exchange column ...
WU Yao, YU Huashun, CHEN Rui, YANG Zhaoshi, LI Ming, GAO Jie, ZHANG Yan   +6 more
doaj   +1 more source

Non-thermal hydrodynamic cavitation processing of tomato juice for physicochemical, bioactive, and enzyme stability: Effect of process conditions, kinetics, and shelf-life extension. [PDF]

Curr Res Food Sci, 2022
Vigneshwaran G, More PR, Arya SS.
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Biochemical characterization and gene structure analysis of the 24‐kDa glutathione transferase sigma from Taenia solium

FEBS Open Bio
Taenia solium can cause human taeniasis and/or cysticercosis. The latter can in some instances cause human neurocysticercosis which is considered a priority in disease‐control strategies and the prevention of mental health problems.
Ricardo Miranda‐Blancas, Oscar Rodríguez‐Lima, Ponciano García‐Gutiérrez, Roberto Flores‐López, Lucía Jiménez, Rafael A. Zubillaga, Enrique Rudiño‐Piñera, Abraham Landa   +7 more
doaj   +1 more source

Enhancing Enzyme Stability for Biotechnological Applications

CHIMIA
Enzymes are emerging as a central element of green chemistry due to their high selectivity, biodegradability, and biocompatibility. However, their application in biotechnology is often limited by their poor stability under non-native conditions.
Ana I. Benítez-Mateos
doaj   +1 more source