Stability assessment of enzyme stabilized road embankments
MATEC Web of Conferences, 2017 Road infrastructure is one of the most important factors for a country’s development. The vital role that they play in the present economy is reflected in many kilometres of roads worldwide.
Singh Jaspreet +6 more
doaj +1 more source
Research Progress in Enzyme Engineering Strategies to Improve the Thermal Stability of Enzymatic Time-Temperature Indicators [PDF]
Shipin KexueFood safety is paramount to the health of consumers. Enzymatic time-temperature indicators are capable of monitoring the cumulative heat exposure after the production of food products and providing visual color changes indicative of product shelf life ...
PENG Huakang, ZHANG Huanzhi, WANG Chenyue, WANG Yao
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Glycosylation increases active site rigidity leading to improved enzyme stability and turnover. [PDF]
FEBS J, 2023 Ramakrishnan K +12 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A Review of Enzyme Immobilization Methods and Critical Parameters for Evaluating Immobilized Enzymes [PDF]
Journal of Mazandaran University of Medical SciencesEnzymes, natural biocatalysts with high catalytic efficiency, are essential in numerous biological and industrial processes. However, their inherent instability and sensitivity to environmental conditions often limit their direct application.
Mehdi Aghaee, Mehdi Mogharabi-Manzari
doaj
Local Conformational Constraint of Firefly Luciferase Can Affect the Energy of Bioluminescence and Enzyme Stability. [PDF]
CCS Chem, 2022 Zhang C +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source