Local Conformational Constraint of Firefly Luciferase Can Affect the Energy of Bioluminescence and Enzyme Stability. [PDF]
CCS Chem, 2022 Zhang C +4 more
europepmc +1 more source
Malic enzyme 2 as a therapeutic target for cancer: comments on ‘Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate’ [PDF]
, 2022 Zhenxi Zhang, Wenjing Du
openalex +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability. [PDF]
J Biol Chem, 2022 Shukla PK +9 more
europepmc +1 more source
STABILITY OF Staphylococcus aureus BIOFILM AGAINST DIFFERENT CHEMICAL AGENTS AND SOME ENZYMES [PDF]
, 2016 Omar, Belal A.M. +3 more
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Structure Guided Drug Designing Coupled to Advanced Molecular Dynamics Revealed Differential Binding Properties (Affinity/Stability) of Celecoxib and Niflumic Acid in the Active Site of Cyclooxygenase-2 Enzyme [PDF]
, 2022 Shabir Ahmad Ganai +4 more
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Lactose hydrolysis by immobilized whole cells of K. lactis CBS 2357 : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Bioprocess Engineering at Massey University [PDF]
, 1999 The application of immobilized yeast for lactose hydrolysis was investigated. The enzyme stability was tested as a function of pretreatment. The stability of K.
Marasabessy, Ahmad
core
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Non-Aqueous Biocatalysis in Homogeneous Solvent Systems
Food Technology and Biotechnology, 2004 Enzymes are highly specific catalysts that typically function in aqueous solvents. However, many enzymes retain their catalytic activities at high concentrations in non- aqueous environments, including neat hydrophilic organic solvents.
Sebastián Torres, Guillermo R. Castro
doaj
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source