Monitoring the rotary motors of single FoF1-ATP synthase by synchronized multi channel TCSPC [PDF]
Confocal time resolved single-molecule spectroscopy using pulsed laser excitation and synchronized multi channel time correlated single photon counting (TCSPC) provides detailed information about the conformational changes of a biological motor in real time.
arxiv +1 more source
Accelerated search kinetics mediated by redox reactions of DNA repair enzymes [PDF]
A Charge Transport (CT) mechanism has been proposed in several papers (e.g., Yavin, et al. PNAS, v102 3546 (2005)) to explain the localization of Base Excision Repair (BER) enzymes to lesions on DNA. The CT mechanism relies on redox reactions of iron-sulfur cofactors that modify the enzyme's binding affinity.
arxiv +1 more source
Performance of immobilized bacterial alpha-amylases in methyltriethoxsilane / tetraetoxysilane sol-gel matrices [PDF]
The large number of studies related to the field of biomolecules encapsulation in sol-gel hosts clearly indicates that this approach can be considered as a powerful alternative to traditional encapsulation procedures involving biopolymer hosts.
Dudás, Zoltán Imre+2 more
core
Immobilization of Enzymes in Protein Films [PDF]
Heterogeneous biocatalysis usually involves the use of immobilized enzymes on solid supports. Enzymes have suitable properties in terms of efficiency and selectivity for use as immobilized catalysts. Different approaches have been developed for effective immobilization, including adsorption, covalent binding, entrapment, encapsulation, and cross ...
Sanchez-deAlcazar, D+2 more
openaire +4 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla+9 more
wiley +1 more source
Immobilization of Pectinolytic Enzymes on Nylon 6/6 Carriers
Pectinolytic enzymes are an important tool for sustainable food production, with a wide range of applications in food processing technologies as well as the extraction of bioactive compounds from pectin-rich raw materials.
Sana Ben-Othman, Toonika Rinken
doaj +1 more source
The use of immobilized enzymes as biocatalysts in organic syntheses is of increasing interest. Immobilized enzymes are enzymes attached to carries via physical or chemical interactions, thus making them to be easily handled as compared to their soluble ...
Abdul Rahman, Mohd Basyaruddin+4 more
core
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan+10 more
wiley +1 more source
Enzymes immobilized in wood-derived cellulose scaffold for constructing a novel modular bioreactor
Modular bioreactors can provide a flexible platform for constructing complex multi-step pathways, which may be a solution for maximizing reactions and overcoming the complexity of multi-enzyme systems. Here, we selected wood-derived cellulose scaffold as
Zhihong Zhang+5 more
doaj
Substrates modulate charge-reorganization allosteric effects in protein-protein association [PDF]
Protein function may be modulated by an event occurring far away from the functional site, a phenomenon termed allostery. While classically allostery involves conformational changes, we recently observed that charge redistribution within an antibody can also lead to an allosteric effect, modulating the kinetics of binding to target antigen.
arxiv