Results 161 to 170 of about 2,028,343 (313)

Functional conservation with mechanistic drift: AMP activation in the evolution of archaeal sugar kinases. [PDF]

Mol Biol Evol
M Herrera S, Vallejos-Baccelliere G, Malavé D, Hernández-Cabello L, Castro-Fernandez V, Guixé V.   +5 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Safety evaluation of a food enzyme containing oryzin and leucyl aminopeptidase activities and a heat-treated food enzyme containing only leucyl aminopeptidase activity from the non-genetically modified <i>Aspergillus</i> sp. strain FL 72-230. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Van Loveren H, Vernis L, Andreoli C, Terron A, Cavanna D, Aguilera J, Andryszkiewicz M, Kovalkovicova N, Peluso S, de Sousa RF, Liu Y.   +21 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Applications of microbial enzymes in the textile industry

, 2012
Textile industry is a conventional industry in many countries, which possesses a considerable proportion of the economy. In recent years, special attention has been paid to the application of biotechnology in textile industries (Mahmoud et al., 2009 ...
Erden E., Kasikara Pazarlioglu N.
core  

A cloaked glutamate decarboxylase sustains the GABA shunt in <i>Mycobacterium tuberculosis</i>. [PDF]

Proc Natl Acad Sci U S A
Thai HM, Hunt DM, Miyahara Y, Priya M, Aung HL, Zallot R, de Carvalho LPS.   +6 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Safety evaluation of the food enzyme triacylglycerol lipase from the genetically modified <i>Trichoderma reesei</i> strain DP-Nzk118. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Baviera JMB, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Van Loveren H, Vernis L, Andreoli C, Terron A, Yurkov A, Gomes A, Cavanna D, Fernández-Fraguas C, Kovalkovičová N, Liu Y.   +20 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source