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Superefficient enzymes

Cellular and Molecular Life Sciences, 2001
Diffusion-controlled enzymes are characterized by second-order rate constants in the range 10(8)-10(10) M(-1)s(-1). These values are at the upper end of the observed rates of many enzyme-substrate reactions and have been predicted by theoretical studies on bimolecular reaction in solution.
Stroppolo, ME   +3 more
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Hybrid enzymes: manipulating enzyme design

Trends in Biotechnology, 1998
Hybrid enzymes are engineered to contain elements of two or more enzymes. Hybrid-enzyme approaches, by taking advantage of the vast array of enzymatic properties that nature has evolved, as well as the strategies that nature has used to evolve them, are becoming an increasingly important avenue for obtaining novel enzymes with desired activities and ...
A E, Nixon, M, Ostermeier, S J, Benkovic
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Enzymes and enzyme models

Comparative Biochemistry and Physiology, 1962
THE determination of mechanisms of enzyme action is among the great problems of modern chemistry (Boyer e t a l . , 1960; Boyer, 1960; Westheimer, 1959). Although not one enzymatic process is today understood, and although no model system has achieved catalytic activity comparable to that of the corresponding enzyme, considerable progress has been made
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Alkylating enzymes

Current Opinion in Chemical Biology, 2013
Chemospecific and regiospecific modifications of natural products by methyl, prenyl, or C-glycosyl moieties are a challenging and cumbersome task in organic synthesis. Because of the availability of an increasing number of stable and selective transferases and cofactor regeneration processes, enzyme-assisted strategies turn out to be promising ...
Ludger A Wessjohann   +3 more
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Molybdenum Enzymes

Essays in Biochemistry, 1999
There are many molybdenum-containing enzymes distributed throughout the biosphere. The availability of molybdenum to biological systems is due to the high water solubility of oxidized forms of the metal. Molybdenum enzymes can be grouped on the basis of the structure of the metal centre.
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DNA enzymes

Current Opinion in Chemical Biology, 1998
The past year has seen a coming-of-age in DNA enzyme research. Far from being laboratory curiosities, the activities of new DNA enzymes have broadened the known catalytic repertoire of nucleic acid enzymes, provided valuable insights into different mechanistic possibilities open to nucleic acid catalysts, and explored the importance for catalysis of ...
D, Sen, C R, Geyer
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Enzyme Informatics

Current Topics in Medicinal Chemistry, 2012
Over the last 50 years, sequencing, structural biology and bioinformatics have completely revolutionised biomolecular science, with millions of sequences and tens of thousands of three dimensional structures becoming available.
Rosanna G, Alderson   +5 more
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