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The Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation

Allergy, EarlyView.
Farm dust extract (FDE) treatment reduces airway eosinophilia, mucus overproduction, and MHC‐II expression on DCs, limiting antigen presentation and Th2 inflammation. It increases PD‐L1 on DCs, promoting T cell deactivation. Additionally, FDE enhances Tregs and upregulates CTLA‐4, reinforcing suppression.
Rabia Ülkü Korkmaz +16 more
wiley +1 more source

Decreased Severity of Oral Immunotherapy Induced Gastrointestinal Eosinophilic Reactions Following Revisions in Milk‐Treatment Protocol

Allergy, EarlyView.
A revised milk OIT protocol with lower daily allergen load and slower dose escalation reduced the severity and delayed onset of OIT‐induced gastrointestinal eosinophilic reactions (OITIGER). Elevated baseline absolute eosinophil count (AEC > 600/μL) was a consistent independent risk factor for OITIGER, while older age was protective.
Na'ama Epstein‐Rigbi +8 more
wiley +1 more source

A Systematic Review and Meta‐Analysis on the Induction of Confirmed Eosinophilic Esophagitis as a Side Effect of Allergen Immunotherapy: An EAACI Task Force Report

Allergy, EarlyView.
ABSTRACT The European Academy of Allergy and Clinical Immunology (EAACI) established a Task Force to assess the existing data on the relationship between eosinophilic esophagitis (EoE) and allergen immunotherapy (AIT). This systematic review and meta‐analysis aimed to study the incidence of confirmed EoE, developing as a side effect of AIT to food or ...
Carlo Maria Rossi +14 more
wiley +1 more source

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria

Allergy, EarlyView.
ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
T. Zuberbier +221 more
wiley +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh +7 more
wiley +1 more source

Development of Betalactam‐Predictor: A Clinical Decision Tool for Delabeling Low‐Risk Betalactam Allergy Patients. Initial Validation in Penicillin Allergy

Allergy, EarlyView.
BL‐Predictor has emerged as a new tool for delabeling penicillin allergy. External validation has shown a specificity of 93% for detecting low‐risk patients. This score could potentially reduce diagnostic costs and the negative consequences associated with incorrect antibiotic allergy labels.
Marina Labella +14 more
wiley +1 more source

Εosinophilic Chronic Obstructive Pulmonary Disease. What Do We Know So Far?

Pulmonary Therapy
The latest advances in asthma treatment have highlighted the significance of eosinophilia and the possible role of some pro-eosinophilic mediators, like interleukins (IL) IL-5, IL-4/IL-13, and IL-33 in the disease’s pathogenesis.
Konstantinos Bartziokas +5 more
doaj +1 more source

Comorbid Chronic Rhinosinusitis and Asthma: Shared Risk Factors and Treatment Implications—An EAACI Task Force Report

Allergy, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS) and asthma are prevalent conditions that often coexist. These diseases share common inflammatory mechanisms, such as T‐helper cell 2 (T2)‐high inflammation, driven by interleukin (IL)‐4, IL‐5, and IL‐13 cytokines.
Sanna Toppila‐Salmi +21 more
wiley +1 more source

Exhaled Volatile Organic Compounds Identify Allergic Patients Among Individuals With Chronic Rhinitis

Allergy, EarlyView.
Exhaled decane and nonadecane discriminate allergic (AR + LAR) from non‐allergic (NAR + HC) subjects among individuals with chronic rhinitis. LAR patients display higher levels of exhaled nonadecane than NAR individuals at baseline. Subjects with FeNO≥ 25 ppb have higher levels of exhaled decane, nonanal, and styrene than individuals with FeNO < 25 ppb
Rosa Alba Sola‐Martinez +9 more
wiley +1 more source

Nasal Airway Transcriptome Reflects Selected Asthma‐Associated Gene Signatures in the Lower Airways

Allergy, EarlyView.
Seven genes and two gene modules were consistently associated with asthma in both airway compartments in ARMS and were validated in ATLANTIS. The two modules reflected IL‐13 related inflammation and mast cell activity, respectively. Nasal gene signatures provide a non‐invasive proxy for selected bronchial asthma‐associated gene signatures. ARMS, Asthma
Hui Wen +22 more
wiley +1 more source

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