Results 31 to 40 of about 105,068 (238)

Mechanistic Insights into Eosinophilic Esophagitis: Therapies Targeting Pathophysiological Mechanisms

Cells, 2023
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic predisposition (susceptibility loci), environmental triggers (allergens and ...
Sara Massironi, G. Mulinacci, Camilla Gallo, A. Elvevi, Silvio Danese, P. Invernizzi, Edoardo Vespa   +6 more
semanticscholar   +1 more source

A multi-omic analysis reveals the esophageal dysbiosis as the predominant trait of eosinophilic esophagitis

Journal of Translational Medicine, 2023
Background Eosinophilic esophagitis (EoE) is a chronic immune-mediated rare disease, characterized by esophageal dysfunctions. It is likely to be primarily activated by food antigens and is classified as a chronic disease for most patients.
L. Massimino, A. Barchi, F. Mandarino, S. Spanò, L. Lamparelli, E. Vespa, S. Passaretti, L. Peyrin-Biroulet, E. Savarino, V. Jairath, F. Ungaro, S. Danese   +11 more
semanticscholar   +1 more source

Eosinophilic Esophagitis in Children: Clinical Cases

Кубанский научный медицинский вестник, 2022
Background. Eosinophilic esophagitis (Ee) is a chronic immune-mediated disease of the esophagus, which is characterized by symptoms of esophageal dysfunction and marked eosinophilic infiltration of the mucous membrane (MM) of the organ.
A. V. Burlutskaya, A. V. Statova, O. V. Dolbneva, I. I. Borlakova, J. V. Pisotskaya, D. V. Ustyuzhanina   +5 more
doaj   +1 more source

A PhysioMechanical model of esophageal function in eosinophilic esophagitis

Gastroenterology, 2023
Background & Aims: Eosinophilic esophagitis (EoE) is characterized by eosinophilic inflammation, but also heterogeneous presentations involving fibrostenotic esophageal remodeling and esophageal dysmotility.
David Carlson, I. Hirano, N. Gonsalves, P. Kahrilas, IK Araujo, M. Yang, MP Tetreault, JE Pandolfino   +7 more
semanticscholar   +1 more source

MAST CELLS DISTINGUISH EOSINOPHILIC ESOPHAGITIS IN PEDIATRIC PATIENTS

Arquivos de Gastroenterologia, 2017
BACKGROUND: Mast cells exert a substantial role in gastrointestinal allergic diseases. Therefore, it is reasonable to presume that mast cell may aid diagnosis in eosinophilic gastroenteropathy.
Elizete Aparecida LOMAZI, Nelson Ary BRANDALISE, Maria de Fátima Pimenta Correa SERVIDONI, Silvia Regina CARDOSO, Luciana Rodrigues MEIRELLES   +4 more
doaj   +1 more source

Medical treatment of eosinophilic esophagitis

Cochrane Database of Systematic Reviews, 2023
Background Eosinophilic esophagitis (EoE) is a chronic antigen‐mediated eosinophilic inflammatory disease isolated to the esophagus. As a clinicopathologic disorder, a diagnosis of EoE requires a constellation of clinical symptoms of esophageal ...
J. Franciosi, M. Gordon, V. Sinopoulou, E. Dellon, Sandeep K. Gupta, Craig C. Reed, C. Gutiérrez‐Junquera, R. Venkatesh, E. Erwin, A. Egiz, A. Elleithy, E. Mougey   +11 more
semanticscholar   +1 more source

A Practical Update on Pediatric Eosinophilic Esophagitis

Children, 2023
Eosinophilic esophagitis (EoE) is an emerging atopic disease of unknown etiology limited to the esophagus. The pathogenesis is still understood and is likely characterized by type 2 inflammation.
M. Votto, M. De Filippo, S. Caimmi, C. Indolfi, A. Raffaele, M. Tosca, G. Marseglia, A. Licari   +7 more
semanticscholar   +1 more source

Eosinophilic Esophagitis in Children

Вопросы современной педиатрии, 2016
Eosinophilic esophagitis is a chronic, immune/antigen-mediated esophageal inflammatory disease characterized by a pronounced eosinophilic infiltration of its mucous membrane.
Tatyana N. Budkina, Igor S. Sadikov, Svetlana G. Makarova, Maksim M. Lokhmatov, Aleksandra V. Surzhik, Oksana A. Ereshko   +5 more
doaj   +1 more source

Endoscopic approach to eosinophilic esophagitis: American Society for Gastrointestinal Endoscopy Consensus Conference.

Gastrointestinal Endoscopy, 2022
Endoscopy plays a critical role in caring for and evaluating the patient with eosinophilic esophagitis (EoE). Endoscopy is essential for diagnosis, assessment of response to therapy, treatment of esophageal strictures, and ongoing monitoring of patients ...
S. Aceves, J. Alexander, T. Baron, A. Bredenoord, L. Day, E. Dellon, G. Falk, G. Furuta, N. Gonsalves, I. Hirano, V. Konda, A. Lucendo, F. Moawad, K. Peterson, P. Putnam, J. Richter, A. Schoepfer, A. Straumann, Deborah L. McBride, Prateek Sharma, D. Katzka   +20 more
semanticscholar   +1 more source

Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis

Science immunology, 2023
Allergic diseases are a global health challenge. Individuals harboring loss-of-function variants in transforming growth factor–β receptor (TGFβR) genes have an increased prevalence of allergic disorders, including eosinophilic esophagitis.
K. Laky, Jessica Kinard, J. Li, Ian N. Moore, J. Lack, E. Fischer, J. Kabat, R. Latanich, N. Zachos, Ajinkya R. Limkar, Katherine A. Weissler, Robert W. Thompson, T. Wynn, H. Dietz, A. Guerrerio, P. Frischmeyer-Guerrerio   +15 more
semanticscholar   +1 more source