Results 131 to 140 of about 316,727 (384)

Eosinophils are key regulators of perivascular adipose tissue and vascular functionality

Scientific Reports, 2017
Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension and impaired glucose intolerance.
S. Withers, Ruth Forman, S. Meza-Perez, D. Sorobetea, K. Sitnik, Thomas W. Hopwood, C. Lawrence, W. Agace, K. Else, A. Heagerty, Marcus Svensson-Frej, S. Cruickshank   +11 more
semanticscholar   +1 more source

Neuroprotection and Axonal Regeneration via ECM‐Mimetic Nanofibers Incorporating Metal–Phenolic Network Nanoparticles Toward Spinal Cord Injury Repair

Advanced Science, EarlyView.
Metal–phenolic network (MPN) nanoparticles with neuroprotective functions are integrated into decellularized extracellular matrix (dECM) to obtain biomimetic composite fibrous scaffold MPN@dECM NFs by electrospinning, which protects spared neurons from secondary degeneration by suppressing excitotoxicity and inflammation, and promotes directional ...
Shu Chen, Bixue Wang, Qiya Zhang, Changsheng Liu, Xi Chen   +4 more
wiley   +1 more source

CCL11/CCR3-dependent eosinophilia alleviates malignant pleural effusions and improves prognosis

npj Precision Oncology
Malignant pleural effusion (MPE) is a common occurrence in advanced cancer and is often linked with a poor prognosis. Eosinophils were reported to involve in the development of MPE. However, the role of eosinophils in MPE remains unclear.
Min Zhang, Lixia Xia, Wenbei Peng, Guogang Xie, Fei Li, Chao Zhang, Madiha Zahra Syeda, Yue Hu, Fen Lan, Fugui Yan, Zhangchu Jin, Xufei Du, Yinling Han, Baihui Lv, Yuejue Wang, Miao Li, Xia Fei, Yun Zhao, Kaijun Chen, Yan Chen, Wen Li, Zhihua Chen, Qiong Zhou, Min Zhang, Songmin Ying, Huahao Shen   +25 more
doaj   +1 more source

Mechanisms of eosinophil cytokine release

Memorias do Instituto Oswaldo Cruz, 2005
Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist pre-formed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities
Christianne Bandeira-Melo, Peter F Weller   +1 more
doaj   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

BJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin, J. P. Stone, J. Kerr, A. Geraghty, L. Joseph, A. Montero‐Fernandez, J. K. Wong, J. E. Fildes   +7 more
wiley   +1 more source

Novel Bioresorbable Bone Wax for Potentiated Hemostasis and Osteogenesis

Advanced Science, EarlyView.
The synthesized bioresorbable bone wax material for hemostasis and osteogenesis. The preparation process of the novel resorbable bone wax and its mechanism of accelerating coagulation and promoting osteoregeneration through blood cell aggregation. Abstract Orthopedic surgery faces dual challenges of uncontrolled bleeding and poor bone regeneration at ...
Longbao Feng, Yanbin Lu, Pengyu Fu, Shaojun Li, Pengning She, Yang xiao, Jiaming Ye, Wanqi Li, Shaochuan Li, Wei Xue, Rui Guo   +10 more
wiley   +1 more source

Four-part differential leukocyte count using μflow cytometer [PDF]

, 2010
This paper reports the four-part differential leukocyte count (DLC) of human blood using a MEMS microflow (μflow) cytometer. It is achieved with a two-color laser-induced fluorescence (LIF) detection scheme.
Fridge, Alan, Kasdan, Harvey L., Shi, Wendian, Tai, Yu-Chong   +3 more
core   +1 more source

C5aR1 activation in mice controls inflammatory eosinophil recruitment and functions in allergic asthma [PDF]

, 2023
Anna V. Wiese, Jannis Duhn, Rabia Ülkü Korkmaz, Katharina M. Quell, Ibrahim Osman, Fanny Ender, Torsten Schröder, Ian Lewkowich, Simon P. Hogan, Markus Huber‐Lang, Franziska Gumprecht, Peter König, Jörg Köhl, Yves Laumonnier   +13 more
openalex   +1 more source

PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8+ T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang, Bixue Huang, Yun Li, Zhimou Cai, Yicheng Deng, Xiaoqing Cen, Wei Sun, Jinhong Zhang, Zhenglin Xu, Wenbin Guo, Yi Lyu, Shiyun Luo, Zhesheng Chen, Kexing Lyu, Weiping Wen, Wenbin Lei   +15 more
wiley   +1 more source