Results 131 to 140 of about 234,859 (336)

Do Skin Prick Tests Predict Nasal Provocation Test Outcomes in Allergic Rhinitis Patients?

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background In diagnosing allergic rhinitis (AR), conventional skin prick tests (SPTs) often fail to reflect allergen‐induced nasal symptoms. Conversely, nasal provocation tests (NPTs) provide more definitive assessments but are less accessible.
Yunhyung Lee   +3 more
wiley   +1 more source

Signaling events driving Aspergillus fumigatus-induced eosinophil activation

open access: yesInternational Journal of Medical Microbiology
Allergic bronchopulmonary aspergillosis is an incurable disease caused by the environmental mold Aspergillus fumigatus. This hypersensitivity pneumonia is characterized by an inflammatory type 2 immune response, accompanied by influx of eosinophils into ...
Jasmin Adam   +4 more
doaj   +1 more source

Selective PAR2 Inhibition Attenuates HDM‐Induced Th1/Th2 Responses in Human Epithelial and Murine Models of Allergic Rhinitis and Asthma

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Allergic rhinitis (AR) and asthma are involved in complex interactions between Th1 and Th2 inflammatory pathways. House dust mite (HDM) activates protease‐activated receptor 2 (PAR2) to trigger inflammatory responses, but current treatments often provide inadequate control.
Miran Kang   +8 more
wiley   +1 more source

Ozone Inhalation Attenuated the Effects of Budesonide on Aspergillus fumigatus-Induced Airway Inflammation and Hyperreactivity in Mice. [PDF]

open access: yes, 2019
Inhaled glucocorticoids form the mainstay of asthma treatment because of their anti-inflammatory effects in the lung. Exposure to the air pollutant ozone (O3) exacerbates chronic airways disease.
Flayer, Cameron H   +6 more
core  

Dupilumab Initiation for Surgically Refractory Chronic Rhinosinusitis With Nasal Polyps Is Associated With Differential Expression of CLC and Activation of Eicosanoid Pathways

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
Key Points An untargeted transcriptomic analysis provided exploratory insight into key genes and pathways that can be used to help identify patients at risk for surgically refractory chronic rhinosinusitis with nasal polyps (CRSwNP). The Charcot–Leyden crystal gene, periostin and osteopontin‐associated pathways, eicosanoid synthesis pathway, and ...
Christina Dorismond   +10 more
wiley   +1 more source

Factor Analysis‐Based Quantitative Endotyping Improves Associations With CRS Cross‐Sectional and Longitudinal Outcomes

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease characterized by persistent sinonasal inflammation. There is increasing interest in endotype‐based classification, which categorizes CRS based on underlying inflammatory pathways.
Brooke N. Gleason   +16 more
wiley   +1 more source

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