Results 121 to 130 of about 29,712,289 (205)

Ursodeoxycholic Acid Reduces Angiotensin‐Converting Enzyme 2 Activity and Suppresses Cytokine Storm Syndrome in Patients With Coronavirus Disease 2019

MedComm, Volume 7, Issue 9, September 2026.
SARS‐CoV‐2 infection causes COVID‐19 and stimulates immune cells, such as dendritic cells, monocytes, and macrophages, to increase levels of many cytokines. Ursodeoxycholic acid (UDCA) inhibits farnesoid X receptor (FXR), resulting in a decrease in the activity of angiotensin‐converting enzyme 2 (ACE2), the main receptor on the membrane for SARS‐CoV‐2.
Zhaowei Tong, Jiawei Zhu, Jianfeng Zhong, Qi Wang, Fuchu Qian, Lili Zhao, Weihong Wang, Yuepao Cai, Kefeng Qin   +8 more
wiley   +1 more source

Is Asthma Remission a New Achievable Goal? A Review of the Current Drug‐Related Evidence and Predictors

Allergy, Volume 81, Issue 9, Page 3107-3129, September 2026.
ABSTRACT Advances in asthma therapies have shown that clinical remission may be an achievable therapeutic goal for patients with asthma. This review discusses the current definitions of remission in asthma, the predictors of remission, airway inflammation/epithelial damage in asthma remission, airway remodeling, paradigms in defining remission and ...
Fatma Esra Gunaydin, Giulia Marcassa, Bianca Olivieri, Gianenrico Senna, Marco Caminati   +4 more
wiley   +1 more source

Images of immunohistochemical staining of eotaxin-1 in colorectal tissue from patients with CRC

, 2011
Copyright information:Taken from "Analysis of single nucleotide polymorphism in the promoter and protein expression of the chemokine Eotaxin-1 in colorectal cancer patients"http://www.wjso.com/content/5/1/84World Journal of Surgical Oncology 2007;5():84 ...
Anders Hugander (34380), Jan Dimberg (34382), Sture Löfgren (34379), Olaf Dienus (34381), Dick Wågsäter (34378)   +4 more
core   +1 more source

Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma

Allergy, Volume 81, Issue 9, Page 3261-3272, September 2026.
EXPEDITION (NCT02573233) assessed the effects of dupilumab on airway inflammation in patients with persistent asthma using bronchoscopy and gene expression analysis. Dupilumab showed no appreciable effect on inflammatory cell types in biopsies or BALF samples.
Michael E. Wechsler, Sally E. Wenzel, Steve D. Groshong, Mario Castro, Ian D. Pavord, Klaus F. Rabe, Elizabeth Laws, Alexandre Jagerschmidt, Kaitlyn Gayvert, Sivan Harel, Jennifer D. Hamilton, Nikhil Amin, Lu Zhang, Heming Xing, Anissa Elfakir, Bema Coulibaly, Souâd Naimi, Sara Hamon, Paul J. Rowe, Frank Nestle, Danen M. Cunoosamy, Emanuele de Rinaldis, Leda P. Mannent   +22 more
wiley   +1 more source

Heparin and structurally related polymers attenuate eotaxin-1 (CCL11) release from human airway smooth muscle

, 2008
Background and purpose: The glycosaminoglycan heparin has anti-inflammatory activity and is exclusively found in mast cells, which are localized within airway smooth muscle (ASM) bundles of asthmatic airways. Interleukin (IL)-13 induces the production of
C Karner, O'Connor, B J, B J O'Connor, S J Hirst, K Mahn, Karner, C, Kanabar, V, Hirst, S J, Mahn, K, D E Simcock, Page, C, Simcock, D E, V Kanabar, C P Page   +13 more
core   +1 more source

The Airway Transcriptome in Type 2 Cytokine Biomarker‐High and ‐Low Severe Asthma

Allergy, Volume 81, Issue 9, Page 3300-3317, September 2026.
This study distinguishes severe asthma–related airway transcriptomic changes from the effects of high‐dose ICS. Most dysregulated genes in severe asthma show concordance with corticosteroid responses. Corticosteroid‐resistant T2‐high asthma featured T2‐high and epithelial barrier gene upregulation, while T2‐low asthma featured Th1/IL‐17 signatures. ASM,
Jiashu Shen, Rekha Chaudhuri, Stephen Bicknell, Adel H. Mansur, Rahul Shrimanker, Ian D. Pavord, Stephen J. Fowler, Vanessa Brown, Lorcan P. McGarvey, Peter H. Howarth, Sven‐Erik Dahlén, Ian M. Adcock, Nazanin Zounemat‐Kermani, Joseph R. Arron, Liam G. Heaney, David F. Choy, Timothy S. C. Hinks, Emanuele Marchi, Peter Bradding, on behalf of the UK Medical Research Council Refractory Asthma Stratification programme (RASP‐UK)   +19 more
wiley   +1 more source

Linear correlation of TSLP and CCL11/Eotaxin-1 secretion during rhinovirus-induced asthma exacerbation.

, 2016
(A) Positive linear relationship of nasal airway protein levels of TSLP and CCL11/eotaxin-1 in subjects with rhinovirus-induced asthma exacerbation ...
Geovanny F. Perez (2219266), Krishna Pancham (2219281), Humaira Mubeen (2219272), Shehlanoor Huseni (2219275), Justin Wang (422925), Mary C. Rose (410732), Gustavo Nino (183162), Anamaris M. Colberg-Poley (2219278), Stephen Eng (2219269), Dinesh K. Pillai (2219284), Aleeza Abbasi (2219287)   +10 more
core   +1 more source

Eotaxin-3 immunostaining of esophageal biopsy specimens.

, 2014
(A) Normal squamous epithelium shows no eotaxin-3 immunostaining. (B) Eotaxin-3 labels epithelial cells with variable intensity in biopsies with esophageal eosinophilia. (C) High power magnification (1000x) identifies a granular cytoplasmic staining that
Xi Zhang (83736), Nathalie Nguyen (591768), Stuart J. Spechler (252421), Rhonda F. Souza (182856), Jason Y. Park (591767), Edaire Cheng (297727)   +5 more
core   +1 more source

Revisiting CD8+ T Cells in Allergy: The Emerging Role of Tc2 Cells

Scandinavian Journal of Immunology, Volume 104, Issue 3, September 2026.
Tc2 CD8+ T cells in Type 2 inflammation: induction, tissue adaptation, metabolic programming, and therapeutic implications. Both naïve CD8+ T cells and pre‐committed Tc1 CD8+ T cells can be directed towards a Tc2 phenotype, characterised by secretion of the Type 2 cytokines IL‐4, IL‐5, IL‐9 and IL‐13, which in turn drive eosinophil recruitment, goblet ...
Sabrina de Souza Ferreira, Christopher Andrew Tibbitt   +1 more
wiley   +1 more source

Persistence of Increased Eotaxin-1 (CCL11) Level in Tears of Patients Wearing Contact Lenses: A Long-Term Follow-Up Study

, 2011
BACKGROUND: Eotaxin-1 (CCL11) is a potent eosinophil chemotactic and activating peptide that may be implicated in the pathogenesis of chronic allergic eye disease and has been associated with the wearing of contact lenses (CL) in patients with contact ...
Eperon, S., Tran, H.V., Guex-Crosier, Y., S. Eperon, Y. Guex-Crosier, H. Tran   +5 more
core   +1 more source