Results 161 to 170 of about 19,435 (196)

Eotaxin-1-Deficient Mice Develop Airway Eosinophilia and Airway Hyperresponsiveness

International Archives of Allergy and Immunology, 2001
<i>Background:</i> The accumulation of eosinophils in the lung is a hallmark of asthma. In addition to cytokines such as IL-5 which are essential, chemokines have been implicated in the recruitment of eosinophils to the airway. In particular, eotaxin has been shown to be a selective and potent eosinophil chemoattractant, important in the ...
A, Tomkinson, C, Duez, G, Cieslewicz, E W, Gelfand   +3 more
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Production of the chemokine eotaxin‐1 in osteoarthritis and its role in cartilage degradation

Journal of Cellular Biochemistry, 2004
AbstractThe expression of the chemokine, eotaxin‐1, and its receptors in normal and osteoarthritic human chondrocytes was examined, and its role in cartilage degradation was elucidated in this study. Results indicated that plasma concentrations of eotaxin‐1 as well as the chemokines, RANTES, and MCP‐1α, were higher in patients with osteoarthritis (OA ...
Yi-Hsin, Hsu, Ming-Shium, Hsieh, Yu-Chih, Liang, Chao-Yi, Li, Ming-Thau, Sheu, Der-Tsay, Chou, Tzeng-Fu, Chen, Chien-Ho, Chen   +7 more
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Suppressive effects of formoterol and salmeterol on eotaxin-1 in bronchial epithelial cells

Pediatric Allergy and Immunology, 2010
Eotaxin-1 (CCL11), an eosinophil-specific C-C chemokine, is a potent chemoattractant for mobilization of eosinophils into airways after allergic stimulation. Eotaxin-1 recruits eosinophils into inflammatory sites, and may play a role in the pathogenesis of asthma.
Yu-Te, Chu, Tai-Tsung, Chang, Yuh-Jyh, Jong, Po-Lin, Kuo, Hsi-Ming, Lee, Min-Sheng, Lee, Hui-Wen, Chang, Chih-Hsing, Hung   +7 more
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Lack of Association between Eotaxin‐1 Gene Polymorphisms and Nasal Polyposis

Otolaryngology–Head and Neck Surgery, 2011
ObjectiveTo examine whether there is an association of eotaxin‐1 gene polymorphisms with nasal polyposis (NP).Study DesignCross‐sectional study.SettingTertiary referral center.Subjects and MethodsThe study group included 85 patients with NP and 93 controls without sinonasal disease. Genotypes of eotaxin‐1 (−384 A>G and +67 G>A) were identified by
Suna, Ekinci, Selim S, Erbek, Erkan, Yurtcu, Feride I, Sahin   +3 more
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B Cells Secrete Eotaxin-1 in Human Inflammatory Bowel Disease

Inflammatory Bowel Diseases, 2013
Our previous studies have demonstrated that B cells in human inflammatory bowel disease (IBD) are highly activated and produce copious amounts of chemokines. Here, we showed that B cells produce eotaxin-1, a selective chemokine for acute eosinophilia.
Mian Qasim, Rehman, Dominic, Beal, YanMei, Liang, Ansu, Noronha, Harland, Winter, Francis A, Farraye, Lisa, Ganley-Leal   +6 more
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Increase in plasma CCL11 (Eotaxin-1) in patients with alcohol dependence and changes during detoxification

Brain, Behavior, and Immunity, 2022
Alcohol is known to modulate the immune system. Neuroinflammatory cytokine dysregulation plays an essential role in the pathophysiology of alcohol dependence (AD). Preclinical studies have indicated that alcohol consumption upregulates the pro-inflammatory cytokine CC motif ligand 11 (CCL11, also known as eotaxin-1).
Ming-Chyi Huang, Ren-Hua Chung, Pei-Hsuan Lin, Hsiang-Wei Kuo, Tung-Hsia Liu, Ya-Yun Chen, Andrew C.H. Chen, Yu-Li Liu   +7 more
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From airway inflammation to inflammatory bowel disease: Eotaxin-1, a key regulator of intestinal inflammation

Clinical Immunology, 2014
Eotaxin-1 (CCL-11) is a potent eosinophil chemoattractant that is considered a major contributor to tissue eosinophilia. Elevated eotaxin-1 levels have been described in various pathologic conditions, ranging from airway inflammation, to Hodgkin lymphoma, obesity and coronary artery disease.
Ami Ben Ya’Acov, Ariella Bar-Gil Shitrit   +1 more
exaly   +3 more sources

Contribution of Eotaxin-1 to Eosinophil Chemotactic Activity of Moderate and Severe Asthmatic Sputum

American Journal of Respiratory and Critical Care Medicine, 2004
Abstract The CC chemokine eotaxin-1 (CCL11) is chemotactic for eosinophils, basophils, and type 2 helper T cells and may play a role in allergic inflammation. We investigated its contribution as an eosinophil chemoattractant in asthmatic airway secretions (sampled as induced sputum), which possess chemotactic activity for eosinophils ...
Dent, Gordon, Hadjicharalambous, Chrystalleni, Yoshikawa, Takahiro, Handy, Rachel L.C., Powell, John, Anderson, Ian K., Louis, Renaud, Davies, Donna E., Djukanovic, Ratko   +8 more
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Is Eotaxin-1 a serum and urinary biomarker for prostate cancer detection and recurrence?

The Prostate, 2016
Eotaxin-1 (CCL11) is a protein expressed in various tissues influencing immunoregulatory processes by acting as selective eosinophil chemo-attractant. In prostate cancer (PCa), the expression and functional role of CCL11 have not been intensively investigated so far.
Isabel, Heidegger, Julia, Höfer, Markus, Luger, Renate, Pichler, Helmut, Klocker, Wolfgang, Horninger, Eberhard, Steiner, Stefan, Jochberger, Zoran, Culig   +8 more
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Suppressive Effects of Tranilast on Eotaxin-1 Production from Cultured Conjunctival Fibroblasts

Current Eye Research, 2008
Eotaxin, a CC-chemokine with selective chemotactic effects for eosinophils, has been reported to play an important role in allergic conjunctival diseases. We previously reported that eotaxin is produced by conjunctival fibroblasts and keratocytes on stimulation with Th2 cytokines. Tranilast is known to have anti-allergic properties.
Richard Yudi, Hida, Yoji, Takano, Naoko, Okada, Murat, Dogru, Yoshiyuki, Satake, Kazumi, Fukagawa, Hiroshi, Fujishima   +6 more
openaire   +2 more sources