Results 171 to 180 of about 29,712,289 (205)

Smoking Affects Eotaxin Levels in Asthma Patients

Journal of Asthma, 2009
BACKGROUND: Chronic airway inflammation is most important pathological finding in asthma. Cigarette smoking may modify type of inflammation as well as may influence disease severity and response to the treatment. OBJECTIVE: Thus the aim of this study was
Brigita Gradauskiene, Jan Lotvall, Raimundas Sakalauskas   +2 more
exaly   +2 more sources

Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge

Journal of Allergy and Clinical Immunology, 2005
BACKGROUND: Eotaxin-1, eotaxin-2, and eotaxin-3 are chemokines involved in the activation and recruitment of eosinophils through activation of their main receptor, CC chemokine receptor 3.
Pieter Hiemstra, Mauad T, Klaus F Rabe
exaly   +2 more sources

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Eotaxin‐1 is involved in parasite clearance during chronic filarial infection

Parasite Immunology, 2014
SummaryEosinophil migration as key feature of helminth infection is increased during infection with filarial nematodes. In a mouse model of filariasis, we investigated the role of the eosinophil‐attracting chemokine Eotaxin‐1 on disease outcome. BALB/c and Eotaxin‐1−/− mice were infected with the rodent filaria Litomosoides sigmodontis, and parasitic ...
K. Gentil, C. S. Lentz, R. Rai, M. Muhsin, A. D. Kamath, Ö. Mutluer, S. Specht, M. P. Hübner, A. Hoerauf   +8 more
openaire   +2 more sources

Lack of Association between Eotaxin‐1 Gene Polymorphisms and Nasal Polyposis

Otolaryngology–Head and Neck Surgery, 2011
ObjectiveTo examine whether there is an association of eotaxin‐1 gene polymorphisms with nasal polyposis (NP).Study DesignCross‐sectional study.SettingTertiary referral center.Subjects and MethodsThe study group included 85 patients with NP and 93 controls without sinonasal disease. Genotypes of eotaxin‐1 (−384 A>G and +67 G>A) were identified by
Suna, Ekinci, Selim S, Erbek, Erkan, Yurtcu, Feride I, Sahin   +3 more
openaire   +2 more sources

Eotaxin-1-Deficient Mice Develop Airway Eosinophilia and Airway Hyperresponsiveness

International Archives of Allergy and Immunology, 2001
<i>Background:</i> The accumulation of eosinophils in the lung is a hallmark of asthma. In addition to cytokines such as IL-5 which are essential, chemokines have been implicated in the recruitment of eosinophils to the airway. In particular, eotaxin has been shown to be a selective and potent eosinophil chemoattractant, important in the ...
A, Tomkinson, C, Duez, G, Cieslewicz, E W, Gelfand   +3 more
openaire   +2 more sources

B Cells Secrete Eotaxin-1 in Human Inflammatory Bowel Disease

Inflammatory Bowel Diseases, 2013
Our previous studies have demonstrated that B cells in human inflammatory bowel disease (IBD) are highly activated and produce copious amounts of chemokines. Here, we showed that B cells produce eotaxin-1, a selective chemokine for acute eosinophilia.
Mian Qasim, Rehman, Dominic, Beal, YanMei, Liang, Ansu, Noronha, Harland, Winter, Francis A, Farraye, Lisa, Ganley-Leal   +6 more
openaire   +2 more sources

Suppressive effects of formoterol and salmeterol on eotaxin-1 in bronchial epithelial cells

Pediatric Allergy and Immunology, 2010
Eotaxin-1 (CCL11), an eosinophil-specific C-C chemokine, is a potent chemoattractant for mobilization of eosinophils into airways after allergic stimulation. Eotaxin-1 recruits eosinophils into inflammatory sites, and may play a role in the pathogenesis of asthma.
Yu-Te, Chu, Tai-Tsung, Chang, Yuh-Jyh, Jong, Po-Lin, Kuo, Hsi-Ming, Lee, Min-Sheng, Lee, Hui-Wen, Chang, Chih-Hsing, Hung   +7 more
openaire   +2 more sources

Increase in plasma CCL11 (Eotaxin-1) in patients with alcohol dependence and changes during detoxification

Brain, Behavior, and Immunity, 2022
Alcohol is known to modulate the immune system. Neuroinflammatory cytokine dysregulation plays an essential role in the pathophysiology of alcohol dependence (AD). Preclinical studies have indicated that alcohol consumption upregulates the pro-inflammatory cytokine CC motif ligand 11 (CCL11, also known as eotaxin-1).
Ming-Chyi Huang, Ren-Hua Chung, Pei-Hsuan Lin, Hsiang-Wei Kuo, Tung-Hsia Liu, Ya-Yun Chen, Andrew C.H. Chen, Yu-Li Liu   +7 more
openaire   +2 more sources

Is Eotaxin-1 a serum and urinary biomarker for prostate cancer detection and recurrence?

The Prostate, 2016
Eotaxin-1 (CCL11) is a protein expressed in various tissues influencing immunoregulatory processes by acting as selective eosinophil chemo-attractant. In prostate cancer (PCa), the expression and functional role of CCL11 have not been intensively investigated so far.
Isabel, Heidegger, Julia, Höfer, Markus, Luger, Renate, Pichler, Helmut, Klocker, Wolfgang, Horninger, Eberhard, Steiner, Stefan, Jochberger, Zoran, Culig   +8 more
openaire   +2 more sources

Suppressive Effects of Tranilast on Eotaxin-1 Production from Cultured Conjunctival Fibroblasts

Current Eye Research, 2008
Eotaxin, a CC-chemokine with selective chemotactic effects for eosinophils, has been reported to play an important role in allergic conjunctival diseases. We previously reported that eotaxin is produced by conjunctival fibroblasts and keratocytes on stimulation with Th2 cytokines. Tranilast is known to have anti-allergic properties.
Richard Yudi, Hida, Yoji, Takano, Naoko, Okada, Murat, Dogru, Yoshiyuki, Satake, Kazumi, Fukagawa, Hiroshi, Fujishima   +6 more
openaire   +2 more sources