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An Agonist Dependent Allosteric Antagonist of Prostaglandin EP2 Receptors
ACS Chemical Neuroscience, 2020All reported prostaglandin EP2 receptor antagonists have a purely orthosteric, competitive mode of action. Herein, we report the characterization of compound 1 (pubchem CID 664888) as the first EP2 antagonist that features a reversible, agonist dependent allosteric mode of action.
Chunxiang Jiang +2 more
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Discovery of G Protein-Biased EP2 Receptor Agonists
ACS Medicinal Chemistry Letters, 2016 To identify G protein-biased and highly subtype-selective EP2 receptor agonists, a series of bicyclic prostaglandin analogues were designed and synthesized.
Seiji Ogawa +2 more
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Role of EP2 and EP4 receptor-selective agonists of prostaglandin E2 in acute and chronic kidney failure [PDF]
Kidney International, 2006 We tested the efficacy of three selective agonists of prostaglandin E2 (PGE2) receptor, EP2 (CP-536,745-01), EP2/4 (CP-043,305-02), and EP4 (CP-044,519-02), in two models of acute and chronic kidney failure.
David D Thompson, L Grgurević
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EP2: The semiconductor industry in 2025
2010 IEEE International Solid-State Circuits Conference - (ISSCC), 2010The historical predictability of Moore's Law as a law of economics has enabled the semiconductor industry to not only achieve extraordinary innovation, but overtime has redefined how we build complex electronic systems. We have developed an eco-system of specialized entities to solve specific challenges such as Equipment Development, Foundry Services ...
Azeez Bhavnagarwala +3 more
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Complementary roles of EP2 and EP4 receptors in malignant glioma
British Journal of Pharmacology, 2023AbstractBackground and PurposeGlioblastoma (GBM) is the most aggressive brain tumour in the central nervous system, but the current treatment is very limited and unsatisfactory. PGE2‐initiated cAMP signalling via EP2 and EP4 receptors is involved in the tumourigenesis of multiple cancer types. However, whether or how EP2 and EP4 receptors contribute to
Jiange Qiu +9 more
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EP2 and EP4 prostanoid receptor signaling
Life Sciences, 2003The EP(2) and EP(4) prostanoid receptors are two of the four subtypes of receptors for prostaglandin E(2) (PGE(2)). They are in the family of G-protein coupled receptors and both receptors were initially characterized as coupling to Gs and increasing intracellular cAMP formation. Recently, however, we have shown that both receptors can stimulate T-cell
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EP2: Anatomy of innovation: Bug or feature?
2014 IEEE International Solid-State Circuits Conference Digest of Technical Papers (ISSCC), 2014As process scaling slows down, circuit innovation is becoming one of the most important differentiators. We can point to great inventions of the past that were accidental, or failed attempts to solve other problems (bugs), as well as those from logical thinking (features). Which is more effective?
Harry Lee, Ken Nishimura
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Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma
Cell Reports, 2022Jun J Yang, Lexiao Li, Jianxiong Jiang
exaly