Results 11 to 20 of about 692,635 (351)

Use of systematic evidence maps within the US environmental protection agency (EPA) integrated risk information system (IRIS) program: Advancements to date and looking ahead

Environment International, 2022
Systematic evidence maps (SEMs) are increasingly used to inform decision-making and risk management priority-setting and to serve as problem formulation tools to refine the focus of questions that get addressed in full systematic reviews. Within the U.S.
Kristina A. Thayer, Rachel M. Shaffer, Michelle Angrish, Xabier Arzuaga, Laura M. Carlson, Allen Davis, Laura Dishaw, Ingrid Druwe, Catherine Gibbons, Barbara Glenn, Ryan Jones, J. Phillip Kaiser, Channa Keshava, Nagalakshmi Keshava, Andrew Kraft, Lucina Lizarraga, Kristan Markey, Amanda Persad, Elizabeth G Radke, Glenn Rice, Brittany Schulz, Teresa Shannon, Andrew Shapiro, Shane Thacker, Suryanarayana Vulimiri, George Woodall, Erin Yost   +26 more
doaj   +1 more source

Eicosapentaenoic acid and oxypurinol in the treatment of muscle wasting in a mouse model of cancer cachexia [PDF]

, 2012
Cancer cachexia is a wasting condition, driven by systemic inflammation and oxidative stress. This study investigated eicosapentaenoic acid (EPA) in combination with oxypurinol as a treatment in a mouse model of cancer cachexia. Mice with cancer cachexia
Hinch, Edward, Lewandowski, Paul A., Martin, Peter, Sullivan-Gunn, Melanie, Vaughan, Vanessa C.   +4 more
core   +6 more sources

Application of systematic evidence mapping to assess the impact of new research when updating health reference values: A case example using acrolein

Environment International, 2020
Background: The environmental health community needs transparent, methodologically rigorous, and rapid approaches for updating human health risk assessments.
Channa Keshava, J. Allen Davis, John Stanek, Kristina A. Thayer, Audrey Galizia, Nagalakshmi Keshava, Jeff Gift, Suryanarayana V. Vulimiri, George Woodall, Carolyn Gigot, Kelly Garcia, Andrew Greenhalgh, Brittany Schulz, Savannah Volkoff, Krisa Camargo, Amanda S. Persad   +15 more
doaj   +1 more source

EPA and DHA containing phospholipids have contrasting effects on membrane structure

Journal of Lipid Research, 2021
Omega-3 FAs EPA and DHA influence membrane fluidity, lipid rafts, and signal transduction. A clinical trial, Reduction of Cardiovascular Events with Icosapent Ethyl—Intervention Trial, demonstrated that high-dose EPA (4 g/d icosapent ethyl) reduced ...
S. Sherratt, R. Juliano, Christina Copland, Deepak L. Bhatt, P. Libby, R. Mason   +5 more
semanticscholar   +1 more source

Dietary DHA/EPA ratio affects growth, tissue fatty acid profiles and expression of genes involved in lipid metabolism in mud crab Scylla paramamosain supplied with appropriate n-3 LC-PUFA at two lipid levels

Aquaculture, 2021
An 8-week feeding trial was conducted to determine the optimal dietary docosahexaenoic acid/eisosapentaenoic acid (DHA/EPA) ratio of mud crab (Scylla paramamosain) supplied with optimal n-3 LC-PUFA at two dietary lipid levels.
Xuexi Wang, Min Jin, Xin Cheng, Xiaoying Hu, Mingming Zhao, Ye Yuan, P. Sun, Lefei Jiao, M. Betancor, D. Tocher, Qi-cun Zhou   +10 more
semanticscholar   +1 more source

A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study

American Journal of Clinical Nutrition, 2016
Janie Allaire, Patrick Couture, Denis Talbot   +2 more
exaly   +2 more sources

Systematic evidence map (SEM) template: Report format and methods used for the US EPA Integrated Risk Information System (IRIS) program, Provisional Peer Reviewed Toxicity Value (PPRTV) program, and other “fit for purpose” literature-based human health analyses

Environment International, 2022
Background: Systematic evidence maps (SEMs) are gaining visibility in environmental health for their utility to serve as problem formulation tools and assist in decision-making, especially for priority setting.
Kristina A. Thayer, Michelle Angrish, Xabier Arzuaga, Laura M. Carlson, Allen Davis, Laura Dishaw, Ingrid Druwe, Catherine Gibbons, Barbara Glenn, Ryan Jones, J. Phillip Kaiser, Channa Keshava, Nagalakshmi Keshava, Andrew Kraft, Lucina Lizarraga, Amanda Persad, Elizabeth G. Radke, Glenn Rice, Brittany Schulz, Rachel M. Shaffer, Teresa Shannon, Andrew Shapiro, Shane Thacker, Suryanarayana V. Vulimiri, Antony J. Williams, George Woodall, Erin Yost, Robyn Blain, Katherine Duke, Alexandra E. Goldstone, Pam Hartman, Kevin Hobbie, Brandall Ingle, Courtney Lemeris, Cynthia Lin, Alex Lindahl, Kristen McKinley, Parnian Soleymani, Nicole Vetter   +38 more
doaj   +1 more source

Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition

Nutrients, 2020
Life expectancy is increasing and so is the prevalence of age-related non-communicable diseases (NCDs). Consequently, older people and patients present with multi-morbidities and more complex needs, putting significant pressure on healthcare systems ...
B. Troesch, M. Eggersdorfer, A. Laviano, Y. Rolland, A. Smith, Ines Warnke, A. Weimann, Philip C. Calder   +7 more
semanticscholar   +1 more source

Effects of eicosapentaenoic acid intake on denervation-induced mitochondrial adaptation in mouse skeletal muscle

Journal of Physical Fitness and Sports Medicine, 2018
Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid that is abundant in fish oil, and has anti-inflammatory or anti-obesity effects. However, the effects of EPA supplementation on mitochondrial content and dynamics (fusion and fission ...
Kohei Takeda, Yu Kitaoka, Koichi Watanabe, Shumpei Miyakawa, Martin R. Lindley, Tohru Takemasa   +5 more
doaj   +1 more source

A transgenic Camelina sativa seed oil effectively replaces fish oil as a dietary source of eicosapentaenoic acid in mice [PDF]

, 2016
Background: Fish currently supplies only 40% of the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) required to allow all individuals globally to meet the minimum intake recommendation of 500 mg/d.
Betancor, Monica B, Cochard, Marianne, Menoyo, David, Minihane, Anne Marie, Napier, Jonathan A., Rigby, Neil, Ruiz-Lopez, Noemi, Sayanova, Olga, Tejera, Noemi, Tocher, Douglas R., Usher, Sarah, Vauzour, David   +11 more
core   +2 more sources