Results 11 to 20 of about 1,179 (81)

Cell proliferation and glial cell marker expression in the wall of the third ventricle in the tuberal region of the male mouse hypothalamus during postnatal development

Journal of Neuroendocrinology, Volume 35, Issue 3, March 2023., 2023
The postnatal development of the third ventricle ependymal lining is still poorly understood. By analysing cell proliferation using bromodeoxyuridine and the expression profile of a panel of tanycyte and ependymocyte markers (vimentin, S100, connexin‐43 and glial fibrillary acidic protein), we identify the transition between the first and the second ...
Adrian Coutteau‐Robles, Vincent Prevot, Ariane Sharif   +2 more
wiley   +1 more source

Neuronal regulation of glucagon secretion and gluconeogenesis

Journal of Diabetes Investigation, Volume 13, Issue 4, Page 599-607, April 2022., 2022
This article reviews recent data on the identification of hypoglycemia‐sensing neurons in the central nervous system. It discusses how these neurons are connected together to control autonomous nervous activity. It describes key hormonal and nervous responses that prevent hypoglycemia development.
Bernard Thorens
wiley   +1 more source

Peculiar protrusions along tanycyte processes face diverse neural and nonneural cell types in the hypothalamic parenchyma

Journal of Comparative Neurology, Volume 529, Issue 3, Page 553-575, February 2021., 2021
Using TAT‐Cre‐mediated transduction of tdTomato in tanycytes, this study morphologically describes peculiar protrusions along tanycyte processes. Combining tdTomato filling, fluorescence immunohistochemistry and electron microscopy, the authors show in 3D reconstructions the diverse tanycyte partners as well as the subcellular organelles and ...
Roxane Pasquettaz, Irina Kolotuev, Antoine Rohrbach, Cathy Gouelle, Luc Pellerin, Fanny Langlet   +5 more
wiley   +1 more source

Re‐exploring tissue regeneration by novel spatial transcriptomics technologies

, 2022
Clinical and Translational Medicine, Volume 12, Issue 11, November 2022.
Xiaoyu Wei, Hanbo Li, Jiaxin Du, Xiaoqi Zeng, Xun Xu, Liang Chen, Ying Gu   +6 more
wiley   +1 more source

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling

Cell Proliferation, Volume 59, Issue 5, May 2026.
This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha   +9 more
wiley   +1 more source

Mutation of Brain Aromatase Impairs Behavior and Neuroplasticity in Adult Zebrafish

Journal of Neurochemistry, Volume 169, Issue 8, August 2025.
This study investigates the functional role of brain aromatase, encoded by the cyp19a1b gene, in zebrafish neurodevelopment and adult behavior. Using TALENs technology, we introduced a 10‐nucleotide deletion in exon 2, generating a zebrafish line that expresses a truncated aromatase protein.
Cassandra Malleret, Mélanie Blanc‐Legendre, Laëtitia Guillot, Harmony Lautrette‐Quinveros, Pavlina Pavlidi, Christina Dalla, Nikos Kokras, François Brion, Maryne Toupin, Frédéric Chalmel, Xavier Cousin, Thierry Dominique Charlier, Elisabeth Pellegrini   +12 more
wiley   +1 more source

A Novel Method for Culturing Telencephalic Neurons in Axolotls

Journal of Comparative Neurology, Volume 533, Issue 6, June 2025.
A protocol for primary neuron culture from axolotl telencephalon was developed. Spontaneous and axotomy‐induced calcium transients showed excitable cells and neuronal and glial characterization was performed with immunocytochemistry. ABSTRACT The axolotl (Ambystoma mexicanum), a neotenic salamander with remarkable regenerative capabilities, serves as a
Sevginur Bostan, Safiye Serdengeçti, F. Kemal Bayat, Sadık Bay, AyşeServer Sezer, Neşe Ayşit, Gürkan Öztürk   +6 more
wiley   +1 more source

Understanding glucose metabolism and insulin action at the blood–brain barrier: Implications for brain health and neurodegenerative diseases

Acta Physiologica, Volume 241, Issue 2, February 2025.
Abstract The blood–brain barrier (BBB) is a highly selective, semipermeable barrier critical for maintaining brain homeostasis. The BBB regulates the transport of essential nutrients, hormones, and signaling molecules between the bloodstream and the central nervous system (CNS), while simultaneously protecting the brain from potentially harmful ...
Yiyi Zhu, Alexei Verkhratsky, Hui Chen, Chenju Yi   +3 more
wiley   +1 more source

tsRNAs: A Prospective, Effective Therapeutic Intervention for Neurodegenerative Diseases

CNS Neuroscience &Therapeutics, Volume 30, Issue 12, December 2024.
Transfer RNA‐derived small RNAs (tsRNAs) are generated through the cleavage of transfer RNAs. tsRNAs modulate gene expression through transcriptional and translational mechanisms. tsRNAs are implicated in the pathogenesis of neurodegenerative disorders.
Tianqi Li, Hui Zhen, Weiwei Wu, Fengtang Yang, Zhonghong Cao   +4 more
wiley   +1 more source

Lineage tracing of Shh+ floor plate cells and dynamics of dorsal–ventral gene expression in the regenerating axolotl spinal cord

Development, Growth &Differentiation, Volume 66, Issue 8, Page 414-425, October 2024.
How signalling centres drive tissue regeneration after injury is an important question in regenerative research. Here, Arbanas et al. investigated how the floor plate contributes to spinal cord regeneration by developing a transgenic axolotl that lineage traces Shh‐expressing cells in vivo.
Laura I. Arbanas, Emanuel Cura Costa, Osvaldo Chara, Leo Otsuki, Elly M. Tanaka   +4 more
wiley   +1 more source