Results 181 to 190 of about 856,627 (332)
Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib
British Journal of Clinical Pharmacology, EarlyView.Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang +5 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Tranexamic acid (TXA) stabilizes clot formation by inhibiting fibrin degradation and improves postoperative outcomes. However, rare adverse events (e.g., thrombosis, seizures) warrant dose–risk evaluation. This study examines how perioperative blood loss and transfusion practices affect TXA concentrations during paediatric scoliosis surgery ...
Paula Alexandra Sá +4 more
wiley +1 more source
Dependency of Glucose Homeostasis on Pancreatic Enzymes with Special Reference to Amylase; Study on Healthy and Exocrine Pancreatic Insufficient Pigs. [PDF]
BiomoleculesWychowański P +8 more
europepmc +1 more source
Evaluación de las ecuaciones de estimación de la tasa de filtrado glomerular basadas en creatinina sérica CKD-EPI y MDRD en pacientes mexicanos adultos. Estudio piloto [PDF]
, 2020 José Octavio Sosa-Ramos +4 more
openalex +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo +10 more
wiley +1 more source
Biomechanical Impact of Drug Formulation, Supplemental Oxygen, and UV Delivery on Epi-On CXL
, 2019 Desmond C. Adler +5 more
openalex +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Congenital ichthyoses (CI) are rare, inherited skin disorders characterized by hyperkeratosis, scaling and fissuring that significantly impair patients' quality of life. Treatment options are limited, with systemic retinoids reserved for severe cases owing to their adverse effect profile.
Holm Schneider +10 more
wiley +1 more source
Multi-Marker Evaluation of Creatinine, Cystatin C and β2-Microglobulin for GFR Estimation in Stage 3-4 CKD Using the 2021 CKD-EPI Equations. [PDF]
Int J Mol SciAbu Bakar N +6 more
europepmc +1 more source