Results 21 to 30 of about 55,561 (264)

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Detection and Characterization of Circulating Tumour Cells in Multiple Myeloma

Journal of Circulating Biomarkers, 2016
Multiple myeloma (MM) remains an incurable disease despite recent therapeutic improvements. The ability to detect and characterize MM circulating tumour cells (CTCs) in peripheral blood provides an alternative to replace or augment invasive bone marrow ...
Liangxuan Zhang, Sharon Beasley, Natalie L. Prigozhina, Renee Higgins, Shoji Ikeda, Florence Y. Lee, Dena Marrinucci, Shidong Jia   +7 more
doaj   +1 more source

Rethinking planning hierarchy considering climate change as global catastrophe

Climate Risk Management, 2020
This article proposes overcoming the distinction between the effects of climate change and the effects linked to classical disaster hazards by considering Climate Change as global catastrophe.
Mattia Bertin, Francesco Musco, Lorenzo Fabian   +2 more
doaj   +1 more source

An advanced analytical approach to assess the long-term degradation of microplastics in the marine environment

npj Materials Degradation, 2023
Determining the hazards posed by microplastics (MPs,
Carbery Maddison, C. I. Sathish, Daggubati Lakshmi, O’Connor Wayne, Thava Palanisami   +4 more
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Detection and Characterization of Circulating Tumour Cells from Frozen Peripheral Blood Mononuclear Cells

Journal of Circulating Biomarkers, 2015
Retrospective analysis of patient tumour samples is a cornerstone of clinical research. CTC biomarker characterization offers a non-invasive method to analyse patient samples.
David Lu, Ryon P. Graf, Melissa Harvey, Ravi A. Madan, Christopher Heery, Jennifer Marte, Sharon Beasley, Kwong Y. Tsang, Rachel Krupa, Jessica Louw, Justin Wahl, Natalee Bales, Mark Landers, Dena Marrinucci, Jeffrey Schlom, James L. Gulley, Ryan Dittamore   +16 more
doaj   +1 more source

Multi-state models for survival analysis in cardiology: an alternative to composite endpoints

REC: Interventional Cardiology (English Ed.), 2022
To the Editor, The main objective of longitudinal studies conducted in cardiology is often time-to-adverse events (AE) to identify possible risk factors or the efficacy of treatment.
Natalia Montoya, Alicia Quirós, José M. de la Torre-Hernández, Armando Pérez de Prado   +3 more
doaj   +1 more source

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi, Sola Al Ghazal, Salem Hannoun, Medhat A. Siddik, Nour M. Najjar, Jim Dagher, Joseph Abboud, Myriam G. Semaan, Samia J. Khoury   +8 more
wiley   +1 more source

A multicenter randomized single-blinded clinical trial to investigate the effects of an individualized home-based cognitive training program in patients with chronic heart failure: the SYNAPSE protocol

Trials
Background Chronic heart failure patients are at high risk of cognitive deficits, which adds to the cardinal symptoms and can make the clinical picture even more challenging.
Caroll-Ann Blanchette, Florent Besnier, Emma Gabrielle Dupuy, Christine Gagnon, Thomas Vincent, Jean-Lucien Rouleau, Nadia Bouabdallaoui, Josep Iglesies Grau, Normand Racine, François Tournoux, Francisco J. Apullan, Paolo Vitali, Sylvie Belleville, Louis Bherer   +13 more
doaj   +1 more source

A New Era for Educational Assessment

Education Policy Analysis Archives, 2015
In this article, David Conley focuses on how to assess meaningful learning in ways that promote student achievement while simultaneously meeting system accountability needs.
David Conley
doaj   +1 more source