Results 21 to 30 of about 55,697 (267)
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi +8 more
wiley +1 more source
Journal of Circulating Biomarkers, 2015 Retrospective analysis of patient tumour samples is a cornerstone of clinical research. CTC biomarker characterization offers a non-invasive method to analyse patient samples.
David Lu +16 more
doaj +1 more source
npj Materials Degradation, 2023 Determining the hazards posed by microplastics (MPs,
Carbery Maddison +4 more
doaj +1 more source
Addressing Economic Insecurities Can Improve Patient‐Reported Outcomes in Lupus
Arthritis Care &Research, EarlyView.Objective Economic insecurities, such as food, housing, transportation, and financial challenges, are modifiable risk factors and influence patient‐reported outcomes (PROs) in systemic lupus erythematosus (SLE). We examined the following: (1) associations between economic insecurities and PROs, and (2) the impact of screening and addressing economic ...
Jay Patel +8 more
wiley +1 more source
Detection and Characterization of Circulating Tumour Cells in Multiple Myeloma
Journal of Circulating Biomarkers, 2016 Multiple myeloma (MM) remains an incurable disease despite recent therapeutic improvements. The ability to detect and characterize MM circulating tumour cells (CTCs) in peripheral blood provides an alternative to replace or augment invasive bone marrow ...
Liangxuan Zhang +7 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko +4 more
wiley +1 more source
TrialsBackground Chronic heart failure patients are at high risk of cognitive deficits, which adds to the cardinal symptoms and can make the clinical picture even more challenging.
Caroll-Ann Blanchette +13 more
doaj +1 more source
A machine learning approach for single cell interphase cell cycle staging
Scientific Reports, 2021 The cell nucleus is a tightly regulated organelle and its architectural structure is dynamically orchestrated to maintain normal cell function. Indeed, fluctuations in nuclear size and shape are known to occur during the cell cycle and alterations in ...
Hemaxi Narotamo +6 more
doaj +1 more source
Multi-state models for survival analysis in cardiology: an alternative to composite endpoints
REC: Interventional Cardiology (English Ed.), 2022 To the Editor, The main objective of longitudinal studies conducted in cardiology is often time-to-adverse events (AE) to identify possible risk factors or the efficacy of treatment.
Natalia Montoya +3 more
doaj +1 more source