Results 41 to 50 of about 55,697 (267)

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Differential Tissue‐Coupled Powering for Battery‐Free Injectable Electroceuticals

Advanced Science, EarlyView.
A thread‐like injectable neural stimulator is powered through differential tissue‐coupled powering (DTCP), which harvests RF‐frequency tissue potentials with an elongated receiver while preserving a injectable cross‐section. The system integrates an ASIC, stimulation electrodes, and a portable transmitter, enabling wireless peripheral nerve stimulation,
Han Wu, Sultan Mahmud, Mali Halac, Asif Iftekhar Omi, Domenica Sofia Baez Rodas, Jeremiasz Dados, Chaojun Cheng, Anyu Jiang, Cameron Wallace, Anvi Singh, Erin Patrick, Baibhab Chatterjee, Shriya Srinivasan, Adam Khalifa   +13 more
wiley   +1 more source

The role of venture‐financed startups in innovation for US agriculture

American Journal of Agricultural Economics, EarlyView.
Abstract To evaluate the role played by startup companies in the innovation ecosystem of US agriculture, we compile a unique dataset of 6024 new entrants founded 1987–2019 that details their financing lifecycles, annual economic performance, and patenting activities.
Gregory D. Graff, Charles A. W. de Grazia, Nicholas E. Rada   +2 more
wiley   +1 more source

Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular risk factors: the ACTIONcardioRisk protocol

Frontiers in Aging Neuroscience
BackgroundLifestyle factors like exercise and cognitive stimulation might help improve cognitive performance in older adults. However, studies investigating this, reported mixed results.
Louis Bherer, Louis Bherer, Louis Bherer, Tudor Vrinceanu, Emma Gabrielle Dupuy, Emma Gabrielle Dupuy, Mathieu Gayda, Thomas Vincent, Pierre-Olivier Magnan, Pierre-Olivier Magnan, Hanieh Mohammadi, Claudine Gauthier, Claudine Gauthier, Christine Gagnon, Simon Duchesne, Kirk I. Erickson, Daniel Gagnon, Frédéric Lesage, Sonia Lupien, Judes Poirier, Marie-Pierre Dubé, Éric Thorin, Martin Juneau, Juliana Breton, Sylvie Belleville, Sylvie Belleville, Guylaine Ferland, Guylaine Ferland, Flavie Gaudreau-Majeau, Flavie Gaudreau-Majeau, Caroll-Ann Blanchette, Caroll-Ann Blanchette, Paolo Vitali, Anil Nigam, Anil Nigam   +34 more
doaj   +1 more source

Biofilm Exoproteins From Staphylococcus Species Impede Re‐Epithelialization of Nasal Epithelial Cells During Wound Healing and Cease Ciliary Beat Frequency

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Chronic rhinosinusitis (CRS) is an inflammatory disease with many different contributing factors, including bacterial infection. CRS patients are typically managed with medical therapies; however, these treatments frequently fail, leaving surgery as the only viable option.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Emma F. Barry, Lindsay Durr, Kevin Aaron Fenix, P. J. Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Investigating Physical Exercise and Cognitive Training Effects on Cognition and Brain Health in Men and Women with Heart Failure: The ReCARDIO Trial

CJC Open
Cognitive impairment can affect up to 50% of patients with chronic heart failure (CHF) and is associated with reduced treatment adherence, high mortality rates, and poor quality of life.
Louis Bherer, PhD, Florent Besnier, PhD, Christine Gagnon, PhD, Tudor Vrinceanu, PhD, Thomas Vincent, PhD, Hânieh Mohammadi, PhD, Claudine Gauthier, PhD, Corentin Duquesne, MSc, Caroll-Ann Blanchette, MSc, Béatrice Bérubé, MSc, Stéphane-Nassif Said, Josep Iglesies-Grau, MD, PhD, Philippe L'Allier, MD, Jacinthe Boulet, MD, Anil Nigam, MD, Valérie Dionne, MSc, Hakima Benhalima, Marie-Pierre Dubé, PhD, Simon Duchesne, PhD, Sylvie Belleville, PhD, Patrice Brassard, PhD, Daniel Gagnon, PhD, Frédéric Lesage, PhD, Mathieu Gayda, PhD, Jean-Paul Soucy, MD, Nadia Bouabdallaoui, MD, PhD, Teresa Liu-Ambrose, PhD, Cindy Barha, PhD, Judes Poirier, PhD, Éric Thorin, PhD, Minh Vu, MD, François Tournoux, MD, PhD, Paolo Vitali, MD, PhD, Eileen O’Meara, MD, Normand Racine, MD, Jean-Lucien Rouleau, MD   +35 more
doaj   +1 more source

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Smart Urban Living: Enabling Emotion-Guided Interaction With Next Generation Sensing Fabric

IEEE Access, 2020
With the rapid development of technologies, such as 5G, cloud computing, and artificial intelligence, smart cities are gradually being implemented from a concept to actual development and deployment.
Yingying Jiang, Wenjing Xiao, Rui Wang, Ahmed Barnawi   +3 more
doaj   +1 more source

Extent of Sinus Surgery Is Associated With Disease Control in Biologic Treated Type 2 Dominant CRS

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background A greater benefit of biologics is observed after surgery in Type 2 chronic rhinosinusitis with nasal polyps (CRSwNP). However, the extent of surgery remains undefined in many studies. This study evaluated the extent of surgery on disease control in patients receiving biologics for refractory Type 2 dominant CRSwNP.
Nicholas J. Campion, Peta‐Lee Sacks, Lu Hui Png, Ruoxin Hua, Rhea Darbari Kaul, Raquel Alvarado, Christine Choy, Raymond Sacks, Peter Earls, Raewyn G. Campbell, Larry Kalish, Richard J. Harvey   +11 more
wiley   +1 more source

High output power low temperature polysilicon thin-film transistor boost converters for large-area sensor and actuator applications

npj Flexible Electronics
Large-area electronic sensor and actuator arrays are suitable systems for thin-film transistor (TFT) technology with numerous applications from consumer electronics to healthcare. Considerable effort is being spent to make these arrays a reality. However,
Mauricio Velazquez Lopez, Nikolas Papadopoulos, Paoline Coulson, Bjorn Vandecasteele, Kris Myny   +4 more
doaj   +1 more source