Results 61 to 70 of about 19,087 (225)

GLP‐1 Receptor Agonists in Metabolic Dysfunction‐Associated Steatotic Liver Disease: Bridging Hepatic and Cardiovascular Outcomes

Chronic Diseases and Translational Medicine, EarlyView.
Endogenous GLP‐1 and exogenous GLP‐1 RAs activate GLP‐1R‐expressing vagal afferents in the portal vein, projecting to the nucleus tractus solitarius (NTS). This input engages brainstem–hypothalamic circuits that regulate metabolic homeostasis. Hypothalamic efferent vagal output to the liver suppresses lipogenesis, enhances triglyceride export, and ...
Gabriel Amorim Moreira Alves, Masatoki Teranishi, Rajendranandini Majumdar, Fazal Khan, Mohan Dodeja, Ana Claudia Teixeira de Castro Gonçalves Ortega, Marco Acerboni, Arosh S. Perera Molligoda Arachchige, Frank James   +8 more
wiley   +1 more source

Cardioprotective properties of omentin-1 in type 2 diabetes: evidence from clinical and in vitro studies. [PDF]

PLoS ONE, 2013
CONTEXT: Adipokines are linked to the development of cardiovascular dysfunction in type 2 diabetes (DM2). In DM2-patients, circulating levels of omentin-1, an adipokine preferentially expressed in epicardial adipose tissue, are decreased.
Sabrina Greulich, Weena J Y Chen, Bujar Maxhera, Luuk J Rijzewijk, Rutger W van der Meer, Jacqueline T Jonker, Heidi Mueller, Daniella Herzfeld de Wiza, Ralf-Ruediger Floerke, Konstantinos Smiris, Hildo J Lamb, Albert de Roos, Jeroen J Bax, Johannes A Romijn, Jan W A Smit, Payam Akhyari, Artur Lichtenberg, Juergen Eckel, Michaela Diamant, D Margriet Ouwens   +19 more
doaj   +1 more source

IMMUNOPHENOTYPE OF MESENCHYMAL STEM CELLS FROM ADIPOSE TISSUE OF PATIENTS WITH CARDIOVASCULAR DISEASES

Байкальский медицинский журнал, 2023
Introduction. Due to a set of unique properties, for example, the ability to differentiate into different types of connective tissue cells, mesenchymal stem cells (MSCs) are attracting more and more attention from researchers.
Evgeniya Gennadievna Uchasova, Julia Alexandrovna Dyleva, Ekaterina Vladimirovna Belik, Vera Gennadievna Matveeva, Sergey Mikhailovich Gusev, Olga Victorovna Gruzdeva   +5 more
doaj   +1 more source

Body mass index, abdominal fatness, fat mass and the risk of atrial fibrillation: a systematic review and dose–response meta-analysis of prospective studies [PDF]

, 2017
Different adiposity measures have been associ- ated with increased risk of atrial fibrillation, however, results have previously only been summarized for BMI. We therefore conducted a systematic review and meta- analysis of prospective studies to clarify
Aune, D, Janszky, I, Norat, T, Riboli, E, Romundstad, P, Schlesinger, S, Sen, A, Tonstad, S, Vattan, LJ   +8 more
core   +1 more source

Osteocalcin and epicardial adipose tissue in obesity: new hints for epicardial adipose tissue–bone crosstalk

Scandinavian Cardiovascular Journal, 2019
Objectives: Osteocalcin (OC) appears to be involved in the regulation of glucose and fat metabolism. We aimed to determine the association between OC and epicardial adipose tissue (EAT) in premenopausal obese women. Design: The study included 73 premenopausal obese women and 55 non-obese women. Echocardiographic examination was performed to measure EAT.
Dedeoğlu, O., Şenol, Hande, Yaylalı, Yalın Tolga, Fidan-Yaylalı, Güzin   +3 more
openaire   +3 more sources

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Association of familial Mediterranean fever and epicardial adipose tissue: A systematic review and meta‐analysis

Health Science Reports, 2022
Background and Aim Some studies reported a positive link between familial Mediterranean fever (FMF) and epicardial adipose tissue. Our meta‐analysis aimed to evaluate whether there is a significant association between FMF and increased epicardial adipose
Karam R. Motawea, Omneya A. Kandil, Joseph Varney, Merna Aboelenein, Nancy Ibrahim, Ahmed Shaheen, Lina T. Khairy, Agyad Bakkour, Ali H. H. Muwaili, Dhuha H. H. Muwaili, Fatima A. A. Abdelmajid, Eman M. S. Ahmad, Mhd K. Albuni, Elias Battikh, Bisher Sawaf, Sarya Swed, Safaa M. A. Ahmed, Dina M. Awad, Jaffer Shah, Hani Aiash   +19 more
doaj   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Association of Region‐Specific Cardiac Adiposity With Dysglycemia and New‐Onset Diabetes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Visceral adipose tissue is assumed to be an important indicator for insulin resistance and diabetes beyond overweight/obesity. We hypothesized that region‐specific visceral adipose tissue may regulate differential biological effects for new ...
Kuo‐Tzu Sung, Jen‐Yuan Kuo, Chun‐Ho Yun, Yueh‐Hung Lin, Jui‐Peng Tsai, Chi‐In Lo, Chih‐Chung Hsiao, Yau‐Huei Lai, Cheng‐Ting Tsai, Charles Jia‐Yin Hou, Cheng‐Huang Su, Hung‐I Yeh, Chen‐Yen Chien, Ta‐Chuan Hung, Chung‐Lieh Hung   +14 more
doaj   +1 more source

Pericardial Fat Is Associated with Coronary Artery Calcification in Non-Dialysis Dependent Chronic Kidney Disease Patients [PDF]

, 2014
Pericardial fat (PF) a component of visceral adipose tissue has been consistently related to coronary atherosclerosis in the general population. This study evaluated the association between PF and coronary artery calcification (CAC) in non-dialysis ...
Canziani, Maria Eugênia Fernandes, Cuppari, Lilian, Draibe, Sergio Antonio, Harada, Paulo H. N., Kalil Filho, Roberto, Kamimura, Maria Ayako, Lemos, Marcelo M., Lima, Leonardo M., Rochitte, Carlos E., Santos, Raul D.   +9 more
core   +6 more sources