Results 191 to 200 of about 396,894 (342)

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

SUPPLEMENTAL TABLE 1 from Comparison of Collection Methods for Fecal Samples for Discovery Metabolomics in Epidemiologic Studies

, 2023
Erikka Loftfield, Emily Vogtmann, Joshua N. Sampson, Steven C. Moore, Heidi D Nelson, Rob Knight, Nicholas Chia, Rashmi Sinha   +7 more
openalex   +1 more source

Multi‐Omics Reveal the Dysregulated Gut‐Joint Axis in Knee Synovitis: Data from Two Osteoarthritis Studies in China

Advanced Science, EarlyView.
The “gut‐joint axis” in knee synovitis is uncovered. Integrated multi‐omics studies are conducted in two independent osteoarthritis cohorts. Synovitis is characterized an increased F/B ratio, as well as alterations of 3‐HIA, geranic acid, and TWEAK. Upregulated TWEAK receptor is found in high‐grade synovitis, and inversely correlated with lower TWEAK ...
Xiaoshuai Wang, Yi Liu, Ziying Sun, Jia Li, Zhihao Lu, Jiayuan Huang, Shixian Hu, Peihua Cao, Xiaolong Cao, Shangru Li, Jianzhao Ruan, Jinhui Liu, Jingyu Xie, Haitao Sun, Tianyu Chen, Shengfa Li, Zhaohua Zhu, Zhibo Wen, Rocky S. Tuan, David John Hunter, Zhong Alan Li, Dongquan Shi, Changhai Ding   +22 more
wiley   +1 more source

Artistic gymnastics-specific extension of the IOC 2020 consensus statement: methods for recording and reporting of epidemiological data on injury and illness in sport [PDF]

Ellen Casey, Tejal Sarika Patel, Joao Francisco Almedia, J Binder, Jonathan Bucke, Kenneth Duffy, Marcia Faustin, Yasunobu Iwasaki, David W. Kruse, Jason Laird, Torrance Laury, Jean Mathieu, J. M. Rigg, Chris Tomlinson, Cheryl Thomas, Keith Stokes   +15 more
openalex   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Developing public health policy for addressing PCOS is hampered by the paucity of high-quality epidemiologic studies. [PDF]

J Endocr Soc
Azziz R, Rudd M.
europepmc   +1 more source

Epidemiological methods: Italian contributions.

Epidemiologia e prevenzione, 2010
F. Barbone, BIGGERI, ANNIBALE, CATELAN, DOLORES   +2 more
openaire   +4 more sources

Detection of Mycobacterium tuberculosis strains with MIRU-typing, spoligotyping, and RFLP methods, isolated from Ethiopian patients [PDF]

, 2007
McNerney, R, Ramazanzadeh, R, Traore, H
core  

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

Disentangling the reasons why older adults do not readily participate in cancer trials: a socio-epidemiological mixed methods approach [PDF]

Méoïn Hagège, Michaël Bringuier, Claudia Martinez‐Tapia, C. Chouaïd, Carole Hélissey, Étienne Brain, Godelieve Rochette de Lempdes, Coraline Dubot, Diana Bello-Roufai, Romain Geiss, Emmanuelle Kempf, Audrey Gourden, Hanane Elgharbi, Sonia Garrigou, L Grégoire, Benjamin Derbez, Florence Canouï‐Poitrine   +16 more
openalex   +1 more source