Results 61 to 70 of about 191,448 (256)

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

An empirical method to cluster objective nebulizer adherence data among adults with cystic fibrosis

Patient Preference and Adherence, 2017
Zhe H Hoo,1,2 Michael J Campbell,1 Rachael Curley,1,2 Martin J Wildman1,2 1School of Health and Related Research (ScHARR), University of Sheffield, 2Sheffield Adult Cystic Fibrosis Centre, Northern General Hospital, Sheffield, UK Background: The ...
Hoo ZH, Campbell MJ, Curley R, Wildman MJ   +3 more
doaj  

The Number Needed to Treat: 25 Years of Trials and Tribulations in Clinical Research

Rambam Maimonides Medical Journal, 2015
The number needed to treat (NNT) is a simple measure of a treatment’s impact, increasingly reported in randomized trials and observational studies, but often incorrectly calculated in studies involving varying follow-up times. We discuss the NNT in these
Samy Suissa
doaj   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

For a General Theory of Health: preliminary epistemological and anthropological notes

Cadernos de Saúde Pública
In order to conduct a preliminary evaluation of the conditions allowing for a General Theory of Health, the author explores two important structural dimensions of the scientific health field: the socio-anthropological dimension and the epistemological ...
Naomar de Almeida Filho
doaj  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Study designs: Part 3 - Analytical observational studies

Perspectives in Clinical Research, 2019
In analytical observational studies, researchers try to establish an association between exposure(s) and outcome(s). Depending on the direction of enquiry, these studies can be directed forwards (cohort studies) or backwards (case–control studies).
Priya Ranganathan, Rakesh Aggarwal
doaj   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Método de captura e recaptura: nova metodologia para pesquisas epidemiológicas

Revista de Saúde Pública
O método de captura e recaptura, embora não seja novo, tem sido pouco usado em estudos epidemiológicos. Trata-se de método bem adaptável e adequado para estudar populações incomuns ou esquivas, como usuários de drogas endovenosas.
John Dunn, Sérgio Baxter Andreoli
doaj  

Antimicrobial Use and Antimicrobial Resistance: A Population Perspective

Emerging Infectious Diseases, 2002
The need to stem the growing problem of antimicrobial resistance has prompted multiple, sometimes conflicting, calls for changes in the use of antimicrobial agents.
Marc Lipsitch, Matthew H. Samore
doaj   +1 more source