Results 51 to 60 of about 353,577 (280)

Spreading of Persistent Infections in Heterogeneous Populations [PDF]

, 2010
Up to now, the effects of having heterogeneous networks of contacts have been studied mostly for diseases which are not persistent in time, i.e., for diseases where the infectious period can be considered very small compared to the lifetime of an ...
D. Bleed, D. J. Daley, J. D. Murray, J. Sanz, K. Styblo, K. Styblo, L. M. Floría, R. M. Anderson, T. Daniel, Y. Moreno   +9 more
core   +2 more sources

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Bluetongue in Europe and Romania in the Last Years

Scientific Papers Animal Science and Biotechnologies, 2023
Beginning with 2006, in Europe had been a lot of Bluetongue (BT) outbreaks evolving like hemorrhagic disease in ruminants, caused by bluetongue virus (BTV).
Daniela Moţ, Ileana Nichita, Emil Tîrziu, Teodor Moţ   +3 more
doaj  

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Characterising two-pathogen competition in spatially structured environments [PDF]

, 2014
Different pathogens spreading in the same host population often generate complex co-circulation dynamics because of the many possible interactions between the pathogens and the host immune system, the host life cycle, and the space structure of the ...
Colizza, Vittoria, Meloni, Sandro, Moreno, Yamir, Poletto, Chiara, Van Metre, Ashleigh, Vespignani, Alessandro   +5 more
core   +4 more sources

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

The Complex Systems for Conflict Interaction Modelling to Describe a Non-Trivial Epidemiological Situation

Mathematics, 2022
This study investigates a complex system that describes a non-trivial epidemiological model with integrated internal conflict (interregional migration) on the example of cyclic migration using the software. JetBrains PyCharm Community Edition 2020.3.3, a
Svajone Bekesiene, Igor Samoilenko, Anatolij Nikitin, Ieva Meidute-Kavaliauskiene   +3 more
doaj   +1 more source

Modelling the Minsky triad: A framework to perform reflexive MandS studies [PDF]

, 2012
In this paper, we propose a general framework to evaluate models of systems that are ill defined, incompletely known, and furthermore, which cannot be experimented in real conditions, such as the economical systems at the country scale, epidemics (for ...
Bonte, Bruno, Duboz, Raphaël, Müller, Jean Pierre   +2 more
core  

A systematic review of current knowledge of HIV epidemiology and of sexual behaviour in Nepal [PDF]

, 2002
OBJECTIVE: To systematically review information on HIV epidemiology and on sexual behaviour in Nepal with a view to identifying gaps in current knowledge.
Andrew S. Furber, Baqi S, Bhatt P, Chakraborty AK, Chan R, Chin J, Crofts N, Crofts N, Garg VK, Gurubacharya RL, Gurubacharya VL, James N. Newell, Marianne M. Lubben, Mertens T, Mertens T, Peak A, Poudel P, Seddon D, Shah SA, Shrestha DM, Shrestha J, Shrestha J, Shrestha NM, Shrestha SM, Suvedi BK, Thin RN, Upadhyay P, Upadhyay P   +27 more
core   +1 more source

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source