Results 121 to 130 of about 239,885 (293)

Epidemiological transition of primary cutaneous melanoma in a public hospital in Brazil (1999-2019). [PDF]

An Bras Dermatol, 2023
Ferreira CAZ, Marques LSK, Miot HA, Schmitt JV.   +3 more
europepmc   +1 more source

Programmable Klebsiella pneumoniae Phage Tropism Enabled by Scalable Receptor‐Binding Protein Mining and Modular Assembly

Advanced Science, EarlyView.
This work introduces a scalable, data‐driven strategy that turns the vast sequence diversity of phage receptor‐binding proteins into modular tools for engineering customizable phages. By clustering and experimentally validating diverse RBPs, the authors build an accurate map linking sequence to host specificity and create plug‐and‐play modules that ...
Shisong Jing, Yiyao Song, Xianbiao Bi, Yuqin Song, Dawei Wei, Jiangqing Huang, Yuan Zeng, Gang Zhang, Rong Zhang, Chao Wang, Jie Feng   +10 more
wiley   +1 more source

Epidemiologic Transition in Iran with Emphasis on the Third Stage of Transition

Journal of Community Health Research, 2017
Introduction: During the last half century, all indices of mortality imply the prompt and continuous decrease of nationwide mortality. Alongside reduction of mortality, there happened a comprehensive form of transition of mortality causes, from ...
mohamad sasanipour, Sajjad Asadi
doaj  

The role of age inequalities in cause of death in the slow pace of epidemiological transition in India. [PDF]

Sci Rep, 2022
Yadav S, Perianayagam A, Patel SA, Cunningham SA.   +3 more
europepmc   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Epidemiological transition: a historical analysis of immigration patterns by country of origin (1861-1986) related to circulatory system diseases and all-cause mortality in twentieth-century Australia. [PDF]

BMJ Open, 2023
Kelleher CC, Kelly GE, Segurado R, Briody J, Sellers AM, McCalman J.   +5 more
europepmc   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Commentary: Large variation in the epidemiological transition across countries: is it still valuable as a mortality theory? [PDF]

Int J Epidemiol, 2022
Sudharsanan N, Aburto JM, Riffe T, van Raalte A.   +3 more
europepmc   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

Diferenciais intra-urbanos de mortalidade em Belo Horizonte, Minas Gerais, Brasil, 1994: revisitando o debate sobre transições demográfica e epidemiológica

Cadernos de Saúde Pública
Modelos de transições demográfica e epidemiológica não têm sido debatidos com grande freqüência pela comunidade acadêmica brasileira. Este estudo tem por objetivo rever criticamente os estudos referentes a estes modelos de transição, analisando suas ...
Rômulo Paes-Sousa
doaj