Results 51 to 60 of about 237,522 (297)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Deaths from HIV/AIDS in aged adults in the Federal District

DST, 2020
Introduction: Infection with the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) in Brazil experienced a significant increase in the last decade among individuals aged over 60 years.
Ruth da Conceição Costa e Silva Sacco, Raissa Gomes Magalhães, Amanda de Siqueira Cabral, Patrícia Maria Fonseca Escalda   +3 more
doaj  

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

EPIDEMIOLOGICAL CHARACTERIZATION OF REPORTED CASES OF MENINGOCOCCAL DISEASE IN THE CITY OF SÃO PAULO, BRAZIL, BETWEEN 2019 AND 2025

Brazilian Journal of Infectious Diseases
Introduction: Meningitis is a communicable infectious disease with a significant disease burden and possible unfavorable outcomes. In this context, the World Health Organization (WHO) and the Pan American Health Organization (PAHO) developed the roadmap “
Nathália Amaro Schmidt, Ana Freitas Ribeiro   +1 more
doaj   +1 more source

Incidência do pênfigo vulgar ultrapassa a do pênfigo foliáceo em região endêmica para pênfigo foliáceo: análise de série histórica de 21 anos Incidence of pemphigus vulgaris exceeds that of pemphigus foliaceus in a region where pemphigus foliaceus is endemic: analysis of a 21-year historical series

Anais Brasileiros de Dermatologia, 2011
FUNDAMENTO: Há dois tipos principais de pênfigo: pênfigo vulgar e pênfigo foliáceo. Nos últimos anos, mudanças clínicas e epidemiológicas relacionadas aos pênfigos têm sido observadas.
Gilson Antonio Pereira Gonçalves, Moema Mignac Cumming Brito, Adriana Martinelli Salathiel, Thais Serraino Ferraz, Domingos Alves, Ana Maria Ferreira Roselino   +5 more
doaj   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Descriptive Epidemiology of Interruptions to Free-Living Sitting Time in Middle-Age and Older Adults

, 2021
Descriptive Epidemiology of Interruptions to Free-Living Sitting Time in Middle-Age and Older ...
GN Healy (7347113), JM Blankenship (14535047), David Dunstan (13066443), J Bellettiere (13384674), Paddy Dempsey (14682004), EAH Winkler (14534774), N Owen (9860477)   +6 more
core  

Epidemiology of child psychopathology: major milestones [PDF]

, 2015
Child psychiatric epidemiology has developed rapidly from descriptive, cross-sectional studies in the 1960s to the current large-scale prospective cohorts that unravel aetiological mechanisms.
Tiemeier, Henning, Tiemeier, H.W. (Henning), Verhulst, F.C. (Frank), Verhulst, Frank   +3 more
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Epidemiology of childhood anxiety: longitudinal perspectives [PDF]

, 2011
Introduction: Anxiety is cited as one of the most common mental disorders of youth, with serious implications for academic and social outcomes and future psychopathology.
Gallagher, Sarah Bridie
core