Results 71 to 80 of about 341,208 (342)
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]
, 2020 Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien +12 more
core +2 more sources
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Highly efficient optogenetic cell ablation in C. elegans using membrane-targeted miniSOG. [PDF]
, 2016 The genetically encoded photosensitizer miniSOG (mini Singlet Oxygen Generator) can be used to kill cells in C. elegans. miniSOG generates the reactive oxygen species (ROS) singlet oxygen after illumination with blue light.
Chisholm, Andrew D, Xu, Suhong
core +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Actualización en melanoma incidencia, desarrollo, aspectos biológicos y reporte de caso clínico
Oncología, 2022 El melanoma maligno es una neoplasia originada en los melanocitos que derivan de la cresta neural. La mayoría de estos tumores se desarrollan en la piel en la que los melanocitos se asientan, principalmente a nivel epidérmicos y ocasionalmente en la ...
Gerson Saul Espinoza Vera +1 more
doaj
Anatomía foliar y caulinar de Chascolytrum subaristatum (Poaceae, Pooideae, Poeae)
Lilloa, 2019 El objetivo del presente estudio fue describir la anatomía foliar y caulinar de Chascolytrum subaristatum (Poaceae) presente en áreas naturales de la provincia de Entre Ríos.
María E. Moya +3 more
doaj +1 more source
The Structural Protein of Epidermis
Journal of Investigative Dermatology, 1972 These studies suggest a scheme of keratinization which is unique for epidermal tissue and different from hair and nail. Prekeratin appears to be formed as synthesis of the peptides proceeds or soon after release from the ribosomes. No neutral-soluble precursor in this process can be identified. These newly formed molecules, consisting of 2 or 3 peptide
Lowell A. Goldsmith, Howard P. Baden
openaire +3 more sources
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Foods, 2023 Hawthorn (Crataegus monogyna Jacq.) and whitebeam (Sorbus aria (L.) Crantz) are wild species traditionally used as ethnic foods in the Mediterranean area.
Cristina Tamayo-Vives +9 more
doaj +1 more source