Results 161 to 170 of about 486,968 (249)

Diabetic neuropathy and wound healing: An update on epigenetic crosstalk. [PDF]

World J Diabetes
Sanusi KO, Asiwe JN, Sulaimon FA, Bashar F, Yusuf SK, Abdulkadir HO.   +5 more
europepmc   +1 more source

Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood [PDF]

, 2018
Xunmei Yuan, Kazutaka Tsujimoto, Koshi Hashimoto, Kenichi Kawahori, Nozomi Hanzawa, Miho Hamaguchi, Takami Seki, Makiko Nawa, Tatsuya Ehara, Yohei Kitamura, Izuho Hatada, Morichika Konishi, Nobuyuki Itoh, Yoshimi Nakagawa, Hitoshi Shimano, Takako Takai‐Igarashi, Yasutomi Kamei, Yoshihiro Ogawa   +17 more
openalex   +1 more source

Dynamic Arginine Methylation of YBX1 Relay Controls Its Phase Separation and Chemoradiotherapy Resistance in Rectal Cancer

Advanced Science, EarlyView.
Protein arginine methyltransferase 3 (PRMT3) induces the arginine methylation of Y‐box binding protein 1 (YBX1), which suppresses phase separation and is imperative for its nuclear translocation. Subsequently, lysine‐specific demethylase 4A demethylates YBX1 to unmask the R247 residue and promote its phase separation, which transcriptionally regulates ...
Yunxing Shi, Taixuan Wan, Shaoru Liu, Huashan Liu, Ziwei Zeng, Wenxin Li, Zhenxing Liang, Li Xiong, Shuanglin Luo, Yunfei Yuan, Liang Huang, Liang Kang   +11 more
wiley   +1 more source

5-Hydroxymethylcytosine: a key epigenetic mark in cancer and chemotherapy response. [PDF]

Epigenetics Chromatin
Kharat SS, Sharan SK.
europepmc   +1 more source

Deacetylation of ACLY Mediates RNA M6A‐Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen, Mengqin Shen, Haitao Zhao, Liu Liu, Qian Hua, Xiaoping Zhao, Jianjun Liu, Haizhong Feng, Gang Huang   +8 more
wiley   +1 more source

Dental Ageing Offers New Insights Into the First Epigenetic Clock for Common Dolphins (<i>Delphinus delphis</i>). [PDF]

Ecol Evol
Hanninger EF, Peters KJ, Gerber L, Barratclough A, Betty EL, Palmer EI, Horvath S, Stockin KA.   +7 more
europepmc   +1 more source

Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma

Advanced Science, EarlyView.
IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T. Huse, Bo Chen, Timothy A. Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang   +16 more
wiley   +1 more source

Using epigenetic clocks in environmental epigenetics: recommendations for estimating biological aging in perinatal and pediatric samples. [PDF]

Essays Biochem
England-Mason G.
europepmc   +1 more source

Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition

, 2014
Stephanie M. Tortorella, Simon G. Royce, Paul V. Licciardi, Tom C. Karagiannis   +3 more
openalex   +1 more source

Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model [PDF]

, 2016
Shelly B. Flagel, Sraboni Chaudhury, Maria Waselus, Rebeca Kelly, Salima Sewani, Sarah M. Clinton, Robert C. Thompson, Stanley J. Watson, Huda Akil   +8 more
openalex   +1 more source