Results 181 to 190 of about 486,968 (249)

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source

Beyond genes: a clinician's guide to epigenetics. [PDF]

Breathe (Sheff)
Popov P, Jurkowska RZ.
europepmc   +1 more source

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, EarlyView.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

Unlocking Lung Cancer Cell Dormancy: An Epigenetic Perspective. [PDF]

Int J Mol Sci
Fabrizio FP.
europepmc   +1 more source

Genome-wide germline correlates of the epigenetic landscape of prostate cancer

, 2019
Kathleen E. Houlahan, Yu-Jia Shiah, Alexander Gusev, Jiapei Yuan, Musaddeque Ahmed, Anamay Shetty, Susmita G. Ramanand, Cindy Q. Yao, Connor Bell, Edward O’Connor, Vincent Huang, Michael Fraser, Lawrence E. Heisler, Julie Livingstone, Takafumi N. Yamaguchi, Alexandre Rouette, Adrien Foucal, Shadrielle M. G. Espiritu, Ankit Sinha, Michelle Sam, Lee E. Timms, Jeremy Johns, Ada Wong, Alex Murison, Michèle Orain, Valérie Picard, Hélène Hovington, Alain Bergeron, Louis Lacombe, Mathieu Lupien, Yves Fradet, Bernard Têtu, John D. McPherson, Bogdan Paşaniuc, Thomas Kislinger, Melvin L.K. Chua, Mark M. Pomerantz, Theodorus van der Kwast, Matthew L. Freedman, Ram S. Mani, Housheng Hansen He, Robert G. Bristow, Paul C. Boutros   +42 more
openalex   +2 more sources

Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

Advanced Science, EarlyView.
Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh, Albert Kallon Koroma, Rajeev Kumar Pandey, Yongfang Wang, Jinnan Cheng, Philipp Haas, Mahyar Aghapour, Linda Krug, Adelheid Hainzl, Meinhard Wlaschek, Pallab Maity, Karin Scharffetter‐Kochanek   +11 more
wiley   +1 more source

The clinical use of epigenetics in psychiatry: a narrative review of epigenetic mechanisms, key candidate genes, and precision psychiatry. [PDF]

Front Psychiatry
Montel Hayes R, Mason CE, Miller JJ.
europepmc   +1 more source

From early stress to 12-month development in very preterm infants: Preliminary findings on epigenetic mechanisms and brain growth

, 2018
Monica Fumagalli, Livio Provenzi, Pietro De Carli, Francesca Dessimone, Ida Sirgiovanni, Roberto Giorda, Claudia Cinnante, Letizia Squarcina, Uberto Pozzoli, Fabio Triulzi, Paolo Brambilla, Renato Borgatti, Fabio Mosca, Rosario Montirosso   +13 more
openalex   +2 more sources

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Epigenetic programming reshapes innate immune memory: decoding the molecular imprint of gouty inflammation. [PDF]

Front Pharmacol
Su W, Lu Y, Luo Z, Xiong H.
europepmc   +1 more source