Results 261 to 270 of about 849,922 (340)

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, EarlyView.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source

Comment on "The Effect of Epigenetic Age Acceleration on Atopic Dermatitis: A Mendelian Randomization Study" [Letter]. [PDF]

Clin Cosmet Investig Dermatol
Zhang Z.
europepmc   +1 more source

ChromNet: A Multi‐Task Learning Framework for Cross‐Cell Type Prediction of 3D Chromatin Interactions Using Epigenetic Signals

Advanced Science, EarlyView.
ChromNet enables accurate cross‐cell‐type prediction of chromatin architecture from DNA and epigenetic profiles alone, capturing both conserved and cell‐type‐specific (including disease‐associated) structural features. Its noise‐perturbed multi‐task learning design enhances generalization, enabling precise reconstruction of 3D genome organization even ...
Bin Wang, Shaokai Wang, Liqing Ding, Hongdong Li, Yaohang Li, Jianxin Wang   +5 more
wiley   +1 more source

The role of microRNAs and long non-coding RNAs in epigenetic regulation of T cells: implications for autoimmunity. [PDF]

Front Immunol
Prasad S, Adivikolanu H, Banerjee A, Mittal M, Lemos JRN, Mittal R, Hirani K.   +6 more
europepmc   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Epigenetic signatures, age acceleration, and injury risk in elite female and male soccer players. [PDF]

Sci Rep
Pérez RF, Lecumberri-Arteta J, Kulis M, Botta-Orfila T, Rodríguez-Vilarrupla A, Yanguas X, Ferrer E, Rodas G, Martin-Subero JI.   +8 more
europepmc   +1 more source

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes. [PDF]

Nat Commun
Mavrommatis C, Belsky DW, Ying K, Moqri M, Campbell A, Richmond A, Gladyshev VN, Chandra T, McCartney DL, Marioni RE.   +9 more
europepmc   +1 more source

The epigenomic landscape of transposable elements across normal human development and anatomy [PDF]

, 2019
Choudhary, Mayank N.K., Pehrsson, Erica C., Sundaram, Vasavi, Wang, Ting   +3 more
core   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source