Results 281 to 290 of about 865,085 (290)

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

HNF4α as a Master Regulator of Epigenetic Dynamics in Epithelial Cells. [PDF]

Genes (Basel)
Amicone L, Cicchini C, Marchetti A.
europepmc   +1 more source

The metabolic-epigenetic interface: lysine succinylation orchestrates bidirectional crosstalk in neurodegenerative disorders. [PDF]

Front Neurol
Chai F, Liu C, Liu Y, Zou W.
europepmc   +1 more source

DNA Methylation in Lung Cancer: Predictive Biomarkers for Effective Immunotherapy. [PDF]

Int J Gen Med
Kumari K, Kumar V, Verma C, Hsu PC, Singh A.   +4 more
europepmc   +1 more source

Epigenetic crosstalk between uric acid and vascular health: a role for extracellular vesicles. [PDF]

Clin Epigenetics
Schiano C, Napoli C.
europepmc   +1 more source

Beyond the Genome: Can Epigenetics Forecast Therapeutic Success in Graves' Disease and Thyroid Eye Disease? [PDF]

Int J Mol Sci
Manso J, Sardone D, Marotta V, Salcuni AS, Brunetti A, Cipri C, Sciannimanico SM, Piva L, Carpentieri M, Falchetti A, Vescini F.   +10 more
europepmc   +1 more source

Epigenetic Aging Clocks and Incident Cardiovascular Outcomes: Results From the MESA. [PDF]

J Am Heart Assoc
Srivatsa S, Rice N, Pike JR, Smith JA, Ding J, Liu Y, Budoff M, Bey GS.   +7 more
europepmc   +1 more source

Profiling the epigenetic interplay of lncRNA RUNXOR and oncogenic RUNX1 in breast cancer cells by gene in situ cis-activation.

, 2019
Yuanyuan Nie, Lei Zhou, Hong Wang, Naifei Chen, Lin Jia, Cong Wang, Yichen Wang, Jingcheng Chen, Wen Xue, Chao Niu, Hui Li, Rui Guo, Songling Zhang, Jiuwei Cui, Andrew R. Hoffman, Ji‐Fan Hu, Wei Li   +16 more
openalex   +1 more source