Results 131 to 140 of about 130,267 (286)

Epigenetic variation between urban and rural populations of Darwin’s finches

, 2017
Background The molecular basis of evolutionary change is assumed to be genetic variation. However, growing evidence suggests that epigenetic mechanisms, such as DNA methylation, may also be involved in rapid adaptation to new environments.
Knutie, Sarah A, Clayton, Dale H, Beck, Daniel, Sadler-Riggleman, Ingrid, Skinner, Michael K, Jennifer A. H. Koop, Koop, Jennifer A H, Michael K. Skinner, Daniel Beck, Sarah A. Knutie, Ingrid Sadler-Riggleman, Dale H. Clayton, Sabrina M. McNew, McNew, Sabrina M   +13 more
core   +1 more source

Epigenetic stress memory for predictive and heritable crop epibreeding

Plant Stress
Abiotic stress remains a major challenge to crop productivity, and plants rely on epigenetic regulation to rapidly adjust gene expression through reversible and heritable mechanisms that determine stress memory and phenotypic traits. The understanding of
Mughair Abdul Aziz, Khaled Masmoudi
doaj   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Epigenetic differences linked to phenotypic variation in field and common garden grown Scabiosa columbaria plants

, 2018
Populations often differ in phenotype and these differences can be caused by adaptation by natural selection, random neutral processes, and environmental responses.
Groot, Maartje P., Wagemaker, Niels, Ouborg, Joop, Vergeer, P., Verhoeven, Koen J.F.   +4 more
core   +1 more source

Exploitation of epigenetic variation of crop wild relatives for crop improvement and agrobiodiversity preservation. [PDF]

Theor Appl Genet, 2022
Varotto S, Krugman T, Aiese Cigliano R, Kashkush K, Kondić-Špika A, Aravanopoulos FA, Pradillo M, Consiglio F, Aversano R, Pecinka A, Miladinović D.   +10 more
europepmc   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Association of colorectal cancer with genetic and epigenetic variation in PEAR1-A population-based cohort study. [PDF]

PLoS One, 2022
Yang WY, Izzi B, Bress AP, Thijs L, Citterio L, Wei FF, Salvi E, Delli Carpini S, Manunta P, Cusi D, Hoylaerts MF, Luttun A, Verhamme P, Hardikar S, Nawrot TS, Staessen JA, Zhang ZY.   +16 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Implementation of Epigenetic Variation in Sorghum Selection and Implications for Crop Resilience Breeding. [PDF]

Front Plant Sci, 2021
Ketumile D, Yang X, Sanchez R, Kundariya H, Rajewski J, Dweikat IM, Mackenzie SA.   +6 more
europepmc   +1 more source

Intraspecific variation in the duration of epigenetic inheritance

Abstract Epigenetic inheritance is generally less stable across generations than DNA sequence-based heredity. One common form of epigenetic inheritance, found in plants, fungi, and animals, is the transgenerational memory of gene silencing mediated by small RNAs.
Frejacques, François, Saglio, Marie, Aljohani, Mohammed, Froekjaer-Jensen, Christian, Frézal, Lise, Félix, Marie-Anne   +5 more
openaire   +2 more sources