Results 161 to 170 of about 130,267 (286)

Experimental evidence for short term directional selection of epigenetic trait variation Epigenetic response to selection Authors

Evolution by natural selection can occur when organisms harbor genetically inherited phenotypic variation, and phenotypic variants have differential fitness.
Maury, Stéphane, Latutrie, Mathieu, Mouginot, Pierick, Piquet, Jesaelle, Marin, Sara, Pujol, Benoit, Luviano, Nelia   +6 more
core   +1 more source

Conservation genomics of sibling grouse in boreal forests reveals introgression and adaptive population differentiation in genes controlling epigenetic variation. [PDF]

Zool Res, 2022
Song K, Gao B, Halvarsson P, Fang Y, Klaus S, Jiang YX, Swenson JE, Han ZM, Sun YH, Höglund J.   +9 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Developing approaches to study human epigenetic variation

, 2007
Epigenetics is the study of heritable changes in gene function that occur without a change in the sequence of the DNA, for example DNA methylation and histone modifications.
Bjornsson, Hans Tomas
core  

Investigating the role of epigenetic variation in adaptive responses

, 2020
The contribution of epigenetic modifications to variation in traits and fitness among populations is still largely unknown, but could significantly affect our understanding of adaptation, environmental change, and disease.
Smithson, Mark
core  

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

W1251 Epigenetic Variation of Dnmt3l in Paediatric Ileal Crohn's Disease

, 2010
W1251 Epigenetic Variation of Dnmt3l in Paediatric Ileal Crohn's ...
Richard Saffery (136974), Nicholas C Wong (13609336), Jeffrey Craig (13065240), Musa Drini (230324), Carl D Kirkwood (10975866), Josef Wagner (212644), Don Cameron (369843), Finlay A Macrae (13616587), Anthony G Catto-Smith (17301073)   +8 more
core   +1 more source

High genetic and epigenetic variation of transposable elements: Potential drivers to rapid adaptive evolution for the noxious invasive weed Mikania micrantha. [PDF]

Ecol Evol, 2021
Su Y, Huang Q, Wang Z, Wang T.
europepmc   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Studies into epigenetic variation and its contribution to cardiovascular disease

, 2015
Epigenetic mechanisms regulate cellular gene expression potential without changing the genetic code. Like the genetic sequence, epigenetic marks are faithfully transmitted during mitosis and are generally stable in differentiated cells, but in contrast ...
Talens, R.P.
core