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Understanding natural epigenetic variation
New Phytologist, 2010no ...
Richards, C. +2 more
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The inheritance of acquired epigenetic variations
Journal of Theoretical Biology, 1989There is evidence that the functional history of a gene in one generation can influence its expression in the next. In somatic cells, changes in gene activity are frequently associated with changes in the pattern of methylation of the cytosines in DNA; these methylation patterns are stably inherited. Recent work suggests that information about patterns
Eva, Jablonka, Marion J, Lamb
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Epigenetics Variation and Pathogenesis in Diabetes
Current Diabetes Reports, 2018Great strides have recently been made in elucidating the role of genetic sequence variation in diabetes pathogenesis. Increasingly, studies are focusing on other factors that may contribute to the pathogenesis of diabetes, such as epigenetics, a term "traditionally" encompassing changes to the DNA that do not alter sequence and are heritable (primary ...
Haichen, Zhang, Toni I, Pollin
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Variation in epigenetic inheritance
Trends in Genetics, 1990Changing patterns of DNA methylation may underlie differential gene expression in development. Additional sources of variation in allelic methylation may be introduced by parental differences as well as by gamete of origin.
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Epigenetic Variations in Heredity and Evolution
Clinical Pharmacology & Therapeutics, 2012The biological and medical importance of epigenetics is nowtaken for granted, but the significance of one aspect of it—epigenetic inheritance—is less widely recognized. New datasuggest that not only is it ubiquitous, but both the generationand the transmission of epigenetic variations may be affectedby developmental conditions.
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Epigenetic variation in lingonberries
2021Epigenetic variation plays a role in developmental gene regulation, response to the environment, and in natural variation of gene expression levels. The purpose of the study is to investigate cytosine methylation and secondary compounds of lingonberry (Vaccinium vitis-idaea) among cutting-propagated cultivar Erntedank (ED) and its tissue-culture plants
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2010
Epigenetics is a fast moving field and our understanding of epigenetic mechanisms has dramatically improved in recent decades. We present the role that epigenetics plays in genomic control in humans; the molecular basis of this control and the role that epigenetic aberrations play in the aetiology of human disease.
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Epigenetics is a fast moving field and our understanding of epigenetic mechanisms has dramatically improved in recent decades. We present the role that epigenetics plays in genomic control in humans; the molecular basis of this control and the role that epigenetic aberrations play in the aetiology of human disease.
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Epigenetic Variation and Regulation in Malaria Parasites
Annual Review of Microbiology, 2018Eukaryotic pathogens must survive in different hosts, respond to changing environments, and exploit specialized niches to propagate. Plasmodium parasites cause human malaria during bloodstream infections, where they must persist long enough to be transmitted.
Manoj T, Duraisingh, Kristen M, Skillman
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Epigenetic Epidemiology for Cancer Risk: Harnessing Germline Epigenetic Variation
2012Genetic epidemiology aims to use the natural variation in the genome, namely single nucleotide polymorphisms and copy number variants to look for associations between particular genotypes and disease risk or prognosis. Recent work is now aiming to look further into the genome at the natural variation present in the epigenome, in DNA methylation as well
Kevin, Brennan, James M, Flanagan
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Epigenetic aspects of somaclonal variation in plants
Plant Molecular Biology, 2000Somaclonal variation is manifested as cytological abnormalities, frequent qualitative and quantitative phenotypic mutation, sequence change, and gene activation and silencing. Activation of quiescent transposable elements and retrotransposons indicate that epigenetic changes occur through the culture process.
S M, Kaeppler, H F, Kaeppler, Y, Rhee
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