Results 31 to 40 of about 130,267 (286)
Identification of Type 1 Diabetes-Associated DNA Methylation Variable Positions That Precede Disease Diagnosis [PDF]
, 2011 Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is similar to 50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease.
Busato, F +72 more
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A longitudinal study of epigenetic variation in twins [PDF]
Epigenetics, 2010 DNA methylation is a key epigenetic mechanism involved in the developmental regulation of gene expression. Alterations in DNA methylation are established contributors to inter-individual phenotypic variation and have been associated with disease susceptibility.
Wong, Chloe +7 more
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What role does heritable epigenetic variation play in phenotypic evolution? [PDF]
, 2010 To explore the potential evolutionary relevance of heritable epigenetic variation, the National Evolutionary Synthesis Center recently hosted a catalysis meeting that brought together molecular epigeneticists, experimental evolutionary ecologists, and ...
Richards, Christina L. +2 more
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Epigenetic Variation and Human Disease [PDF]
The Journal of Nutrition, 2002 Cytosine guanine dinucleotide (CpG) island methylation is a known mechanism of epigenetic inheritance in postmeiotic cells. Through associated chromatin changes and silencing, such epigenetic states can influence cellular physiology and affect disease risk and severity.
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Frontiers in Ecology and Evolution, 2022 Ecological genomics approaches have informed us about the structure of genetic diversity in natural populations that might underlie patterns in trait variation.
Jeannie M. Mounger +20 more
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Accessing epigenetic variation in the plant methylome [PDF]
Briefings in Functional Genomics, 2014 Cytosine DNA methylation is the addition of a methyl group to the 5' position of a cytosine, which plays a crucial role in plant development and gene silencing. Genome-wide profiling of DNA methylation is now possible using various techniques and strategies.
Kyung Do, Kim +2 more
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Role of histone methylation in paternal transmission of epigenetic information [PDF]
, 2010 During the development of multi-cellular organisms, one genome gives rise to multiple differentiated cell types. This is achieved by sequence specific transcription factors and different epigenetic mechanisms, which collaborate in reading the genetic ...
Brykczynska, Urszula
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Epigenetic inheritance, epimutation, and the response to selection. [PDF]
PLoS ONE, 2014 There has been minimal theoretical exploration of the role of epigenetic variation in the response to natural selection. Using a population genetic model, I derive formulae that characterize the response of epigenetic variation to selection over multiple
Robert E Furrow
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Epigenetic and epigenomic variation in Arabidopsis thaliana [PDF]
Trends in Plant Science, 2012 Arabidopsis thaliana (Arabidopsis) is ideally suited for studies of natural phenotypic variation. This species has also provided an unparalleled experimental system to explore the mechanistic link between genetic and epigenetic variation, especially with regard to cytosine methylation.
Robert J, Schmitz, Joseph R, Ecker
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Novel insights into the epigenetic regulation of Plasmodium falciparum virulence genes [PDF]
, 2013 Plasmodium falciparum malaria still places a major health burden upon the developing world. The high virulence of this parasite is linked to the variegated expression of single P.
Brancucci, Nicolas Michel Beat
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