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Deutsches Ärzteblatt international, 2010 In addition to the above mentioned article, the possibility of genetic and epigenetic signal transduction should be discussed in addition to the historic Pavlovian reflex. Epigenetics is the discipline that researches how gene expression can be influenced from outside the cell.
openaire +3 more sources
Methylmercury Epigenetics [PDF]
Toxics, 2019 Methylmercury (MeHg) has conventionally been investigated for effects on nervous system development. As such, epigenetic modifications have become an attractive mechanistic target, and research on MeHg and epigenetics has rapidly expanded in the past decade.
Megan Culbreth, Michael Aschner
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Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source
The emerging role of epigenetics in human autoimmune disorders
Clinical Epigenetics, 2019 Epigenetic pathways play a pivotal role in the development and function of the immune system. Over the last decade, a growing body of studies has been published out seeking to explain a correlation between epigenetic modifications and the development of ...
R. Mazzone +6 more
semanticscholar +1 more source
Advances and Promises of Epigenetics for Forest Trees
Forests, 2020 The importance of tree genetic variability in the ability of forests to respond and adapt to environmental changes is crucial in forest management and conservation.
J. Amaral +8 more
semanticscholar +1 more source
Exercise epigenetics and the foetal origins of disease [PDF]
, 2014 Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age).
Dale E, Thomas EW Chalk, William M Brown
core +1 more source
Clinical Epigenetics, 2012 Epigenetics is a mechanism that regulates gene expression independently of the underlying DNA sequence, relying instead on the chemical modification of DNA and histone proteins.
Kubota Takeo +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source
A Polymer Model with Epigenetic Recolouring Reveals a Pathway for the de novo Establishment and 3D Organisation of Chromatin Domains [PDF]
arXiv, 2016 One of the most important problems in development is how epigenetic domains can be first established, and then maintained, within cells. To address this question, we propose a framework which couples 3D chromatin folding dynamics, to a "recolouring" process modelling the writing of epigenetic marks.
arxiv
Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology
Current Issues in Molecular BiologyTechnological advancements in cell-free DNA (cfDNA) liquid biopsy have triggered exponential growth in numerous clinical applications. While cfDNA-based liquid biopsy has made significant strides in personalizing cancer treatment, the exploration and ...
Wan Ying Tan +8 more
doaj +1 more source