Results 121 to 130 of about 175,170 (271)
Epigenetic silencing of RNA polymerase I transcription: a role for DNA methylation and histone modification in nucleolar dominance [PDF]
, 1997 Z. Jeffrey Chen, Craig S. Pikaard
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner +5 more
wiley +1 more source
iTARGET: Interpretable Tailored Age Regression for Grouped Epigenetic Traits [PDF]
arXivAccurately predicting chronological age from DNA methylation patterns is crucial for advancing biological age estimation. However, this task is made challenging by Epigenetic Correlation Drift (ECD) and Heterogeneity Among CpGs (HAC), which reflect the dynamic relationship between methylation and age across different life stages.
arxiv
Nano‐Topography Enhanced Topological‐Cell‐Analysis in Radiation‐Therapy
Advanced Healthcare Materials, EarlyView.Radiotherapy, a treatment that implies exposition of cells to radiation, offers promise to treat cancer. Here, it is hypothesized that the nanoscale details of a scaffold can amplify the response of cells to radiation, measured through topological variables, providing ways to assess the efficacy of Radiotherapy treatment.
Francesca Pagliari +8 more
wiley +1 more source
ELENA: Epigenetic Learning through Evolved Neural Adaptation [PDF]
arXivDespite the success of metaheuristic algorithms in solving complex network optimization problems, they often struggle with adaptation, especially in dynamic or high-dimensional search spaces. Traditional approaches can become stuck in local optima, leading to inefficient exploration and suboptimal solutions.
arxiv
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source