Results 131 to 140 of about 458,162 (417)
Cell size sets the diameter of the budding yeast contractile ring
Nature Communications, 2020 Budding yeast cell polarization is known to self-assemble, but it is still not clear what controls the size of the resulting septin ring. Here the authors show that the septin ring diameter is set by cell volume, ensuring that larger cells have larger ...
I. V. Kukhtevich +4 more
doaj +1 more source
Neurología (English Edition), 2015 Epigenetics is the study of heritable modifications in gene expression that do not change the DNA nucleotide sequence. Some of the most thoroughly studied epigenetic mechanisms at present are DNA methylation, post-transcriptional modifications of histones, and the effect of non-coding RNA molecules.
P. Quesada Jimenez +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou +11 more
wiley +1 more source
Epigenetics of hepatocellular carcinoma
Clinical and Translational Medicine, 2019 In recent years, large scale genomics and genome-wide studies using comprehensive genomic tools have reshaped our understanding of cancer evolution and heterogeneity.
T. Toh, J. Lim, E. Chow
semanticscholar +1 more source
Oxidative stress and epigenetic regulation in ageing and age-related diseases [PDF]
, 2013 Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available ...
Cencioni, Chiara +6 more
core +2 more sources
Molecular Oncology, EarlyView.In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen +17 more
wiley +1 more source
DNMTs are required for delayed genome instability caused by radiation [PDF]
, 2012 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited ...
Anderson, RM +10 more
core +2 more sources
Transcriptome and DNA methylation profiling during the NSN to SN transition in mouse oocytes
BMC Molecular and Cell BiologyBackground During the latter stages of their development, mammalian oocytes under dramatic chromatin reconfiguration, transitioning from a non-surrounded nucleolus (NSN) to a surrounded nucleolus (SN) stage, and concomitant transcriptional silencing ...
Hannah Demond +4 more
doaj +1 more source
Global research progress of gut microbiota and epigenetics: bibliometrics and visualized analysis
Frontiers in ImmunologyBackgroundGut microbiota is an important factor affecting host health. With the further study of the mechanism of gut microbiota, significant progress has been made in the study of the link between gut microbiota and epigenetics.
Siyu Tian, Min Chen
doaj +1 more source
CAPRI enables comparison of evolutionarily conserved RNA interacting regions
Nature Communications, 2019 Comprehensive characterisation of RNA-protein interactions requires different levels of resolution. Here, the authors present an integrated mass spectrometry-based approach that allows them to define the Drosophila RNA-protein interactome from the level ...
Amol Panhale +6 more
doaj +1 more source